Brain State-dependent PCMS in Chronic Stroke
This study is looking at a treatment called Brain state-dependent paired corticomotoneuronal stimulation (PCMS) for people who have difficulty using their hands after a stroke. PCMS combines brain stimulation (transcranial magnetic stimulation or TMS) and nerve stimulation (peripheral nerve stimulation or PNS) to strengthen the connections between your brain and muscles. Researchers want to see if delivering this stimulation at specific, optimal times works better than delivering it at random times to improve hand function. To join, you must have had a stroke more than 6 months ago, have some weakness in your arm and hand, and be able to give consent. The study will measure improvements in your maximum hand force and muscle activation up to one hour after the treatment. The current status of this study is unclear.
- Study design
- This is an interventional study with a planned enrollment of 45 participants. It compares two ways of delivering combined brain and nerve stimulation.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary outcomes, maximum hand force and muscle activation, are measured up to 1 hour after the intervention.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Brain State-dependent PCMS in Chronic Stroke
At a glance
Conditions
NCT04830163
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Texas at Austin
Austin, Texasstudy coordinator listed
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Want this trial checked against your situation?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Maximum hand force outputup to 1 hour after intervention
This will be measured using maximum voluntary contractions of the stroke-affected first dorsal interosseous hand muscle during pinching actions.
- Maximum hand muscle activationup to 1 hour after intervention
This will be measured using electromyography recordings of the stroke-affected first dorsal interosseous muscle during maximum voluntary contractions during pinching actions