Genetic Study of Rotator Cuff Tears: The cuffGEN Study
This study, called cuffGEN, is looking into the genetic causes of rotator cuff tears, which are common shoulder injuries. Researchers want to understand why these tears happen, why some treatments work better for some people, and why some tears come back. They will compare the genes of people with rotator cuff tears (cases) to those without tears (controls) using MRI scans to confirm their condition. The goal is to find common genetic differences that might explain who gets rotator cuff tears and how they respond to treatment. You might be able to join if you are between 40 and 85 years old and have either a confirmed rotator cuff tear or no tear, as shown on an MRI.
- Study design
- This is an observational study aiming to enroll 3500 participants. It is designed to compare the genes of people with and without rotator cuff tears.
- What's involved
- Participants will complete a questionnaire about their medical history, mental health, and expectations for treatment. They will also complete two questionnaires about shoulder pain and function.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary genetic analysis will be measured at 10 years.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Genetic Epidemiology of Rotator Cuff Tears: The cuffGEN Study
At a glance
Conditions
NCT04831164
Where you'd take part
This study runs at 10 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Iowa
Iowa City, Iowastudy coordinator listed
Recruiting
University of Michigan
Ann Arbor, Michiganstudy coordinator listed
Recruiting
University of Texas Southwestern Medical Center
Dallas, Texasstudy coordinator listed
Recruiting
Ohio State University
Columbus, Ohiono site contact published
Not yet recruiting
Beth Israel Deaconess Medical Center
Boston, Massachusettsno site contact published
Completed
Boston Medical Center
Boston, Massachusettsno site contact published
Completed
Brigham and Women's Hospital
Boston, Massachusettsno site contact published
Completed
Orthopedic Institute
Sioux Falls, South Dakotano site contact published
Completed
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Nitin Jain, MD · PRINCIPAL_INVESTIGATOR · University of Michigan
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Genome wide association meta-analysis of cases and controls10 years
Discovery of targeted variants in MRI verified cases and controls