This study is looking at how different lengths of the bypassed intestine during weight loss surgery (Roux-en-Y gastric bypass) affect weight loss and overall health. Researchers are comparing three different lengths: 50 cm, 100 cm, and 150 cm. They want to understand if increasing the bypassed intestine length can lead to better results and how it changes your body's biology and metabolism. This research aims to improve treatments for obesity and related conditions like metabolic syndrome and NASH (a type of liver disease). You might be able to join if you are between 18 and 80 years old, have a Body Mass Index (BMI) between 40-60 kg/m2, and meet your insurance's criteria for weight loss surgery. The study is still recruiting participants.

Study design

This is an interventional study planning to enroll 750 participants. It compares three different surgical procedures (50 cm, 100 cm, or 150 cm biliopancreatic limb length).

What's involved

You would need to have blood collected before and after surgery at specific times, and collect and mail a stool sample before the operation.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for 7 years to measure weight loss and complications after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.