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Observational Study of PPG and Heart Health

This study is looking at how a non-invasive test called Photoplethysmography (PPG) relates to heart health information gathered from an echocardiogram (a type of heart ultrasound). Researchers want to see if PPG, which uses light to detect changes in blood flow, can help predict things like ejection fraction (how well your heart pumps blood) and identify conditions like valvular heart disease or cardiomyopathies (heart muscle diseases). You might be able to join if you are 18 or older and are already scheduled for an echocardiogram at Tulane Medical Center. The main goal is to find a connection between PPG readings and your ejection fraction on the day of your echocardiogram. The current status of this study is unclear.

Study design
This is an observational study planning to include 500 participants. It is a cross-sectional study, meaning data is collected at a single point in time.
What's involved
If you participate, your demographic, health habits, medications, and medical history will be collected from your electronic medical records. You will undergo an echocardiogram as part of your routine care, and PPG recordings will be taken at the same time using a wristband.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, the association between PPG waveforms and ejection fraction, is measured at Day 1, indicating a short follow-up period.

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NCT04843371

PPG to Predict Ejection Fraction and Other Echographic Data in the General Population

Recruiting
Not specifiedAges 18+Observational
Tulane University
~500 participants
Updated 2026-03-05 on ClinicalTrials.gov
What's tested:Photoplethysmography

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Association between obtained PPG waveforms and recorded ejection (EF) fractions.
Measured over Day 1

Conditions

Valvular Heart Disease
Pericardial Disease
Cardiomyopathies

Explore related trials

CardiomyopathyPerianal diseaseStructural Heart DiseaseValvular Heart Disorder

Where it's being run

3 sites across 1 states
Louisiana3

Study leadership

  • Nassir Marrouche, MD · PRINCIPAL_INVESTIGATOR · Tulane University

Who to contact

Mayana Bsoul, MD
[email protected]
504-988-3063
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Male or Female aged18 years or older.
Patients scheduled to undergo an echocardiogram at Tulane Medical Center.

Exclusion

Participants under 18 years of age.
Participants with cognitive impairments.
Participants with a physical inability to wear the Biostrap during the echocardiogram.
Individuals who cannot read, speak, and/or understand English.

What this trial measures

  • Association between obtained PPG waveforms and recorded ejection (EF) fractions.Day 1

    Patients who will undergo echocardiogram will wear the biostrap watch and then the PPG waveform will be obtained. Then, the ejection fraction will be collected from the echocardiogram report. Then, the Artificial Intelligence (AI) staff member will do a predictive model to try and estimate the EF based on the PPG waveform.