Observational Study on Stressors in Adults with Tourette Syndrome
This observational study is looking at how stress throughout your life might affect adults with Tourette Syndrome (TS). Researchers want to understand if stress impacts the severity of tics, other mental health conditions like anxiety or depression, and your overall quality of life. You could be eligible if you are an adult (18 years or older) diagnosed with Tourette Syndrome, chronic motor tic disorder, or chronic vocal tic disorder, can give informed consent, and speak English. The study will measure tic severity using the Yale Global Tic Severity Scale (YGTSS), depression using the NeuroQOL-Depression Score, and quality of life using the Gilles de la Tourette Quality of Life Scale (GTS-QOL) over two years. This study is currently unclear on its recruitment status and does not involve any interventions or treatments.
- Study design
- This is an observational study, meaning it will not test any new treatments. It plans to include 140 adult participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for two years after their initial assessment to measure changes in tic severity, depression, and quality of life.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Longitudinal Impact of Stressors in Adults With Tourette Syndrome
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- David A Isaacs, MD, MPH · PRINCIPAL_INVESTIGATOR · Vanderbilt University Medical Center
Who to contact
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Do you actually qualify for this trial?
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Inclusion
What this trial measures
- Total Tic Score from Yale Global Tic Severity Scale (YGTSS)2 years post-baseline assessment
Semi-structured, clinician-administered interview to assess tic severity. Total tic scores are a composite of motor tic scores (0-25) and phonic tic scores (0-25) based on 5 dimensions of tic severity: number, frequency, intensity, complexity, and interference. Total tic scores range from 0-50. Higher scores indicate great tic severity. The YGTSS is the gold-standard clinical rating scale for tic severity.
- NeuroQOL-Depression Score2 years post-baseline assessment
NeuroQOL-Depression is a validated, 8-item self-report scale assessing symptoms of depression. Raw total scores range from 8-40; raw scores are converted to T-scores based on normative samples. Higher scores indicate more depressive symptoms. NeuroQOL-Depression is part of the Neuro-QOL (Quality of Life in Neurological Disorders) measurement system. The scale is designed to be completed with one minute.
- Gilles de la Tourette Quality of Life Scale (GTS-QOL) Score2 years post-baseline assessment
The GTS-QOL is a 27-item self-report scale. Respondents rate each item on a Likert scale ranging from 0 ("no problem") to 4 ("extreme problem"). The scale is composed of four sub-scales: Psychological (11 items), Physical/Activities of Daily Living (Physical/ADL) (7 items), Obsessive-Compulsive (OC) (5 items), and Cognitive (4 items) (39). Item scores within each subscale are summed and then normalized to 100 to generate the subscale score. The four subscale scores are then summed and normalized to 100 to yield the total score. Higher scores indicate worse health-related quality of life.