Combating Alzheimer's Through Sleep and Exercise

This study is looking at how sleep and exercise might affect the risk of dementia over time. It is testing two interventions: wearing a DREEM 2 Headband for 3 months, which uses brain stimulation and sleep tips to improve sleep, and doing a guided exercise routine twice a week for 3 months. The study aims to enroll 30 participants between 45 and 80 years old who can do mild exercise, wear the headband and a Fitbit, and operate a digital device. Researchers will measure cholesterol levels (Total, HDL, and LDL) up to 12 weeks to see if the interventions are successful. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 30 participants. The phase of the study is not specified.
What's involved
You would wear a DREEM 2 Headband for at least 4 nights a week for 3 months and participate in its digital therapy. You would also do a 30-minute mild circuit training session twice a week for 3 months.
Compensation
Not stated in the trial record.
Follow-up
Researchers will measure cholesterol levels up to 12 weeks after the interventions begin.

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NCT04855630

Combating Alzheimer's Through Sleep and Exercise

Recruiting
NAAges 45–80InterventionalPrevention
University of Miami
~30 participants
Updated 2026-04-20 on ClinicalTrials.gov
What's tested:DREEM 2 HeadbandExercise Routine

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total Cholesterol Levels
Measured over Up to Week 12
+13 more outcomes measured
Alzheimer Disease
Dementia
1 sites across 1 states
Florida1
  • Azizi A Seixas, PhD · PRINCIPAL_INVESTIGATOR · University of Miami

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  • Total Cholesterol LevelsUp to Week 12

    Measured from blood sample

  • High-Density Lipoprotein (HDL) LevelsUp to Week 12

    Measured from blood sample

  • Low-Density Lipoprotein (LDL) LevelsUp to Week 12

    Measured from blood sample

  • Triglycerides LevelsUp to Week 12

    Measured from blood sample

  • High-sensitivity C-reactive protein (hs-CRP) LevelsUp to Week 12

    Measured from blood sample

  • HbA1c LevelsUp to Week 12

    Measured from blood sample

  • Heart RateUp to Week 12

    Measured from Fitbit

  • Blood PressureUp to Week 12

    Measured from Fitbit

  • Total Sleep DurationUp to Week 12

    Measured from DREEM 2

  • Slow Wave Sleep DurationUp to Week 12

    Measured from DREEM 2

  • Cortisol LevelsUp to Week 12

    Measured from Urine Sample

  • Cortisone LevelsUp to Week 12

    Measured from Urine Sample

  • Melatonin LevelsUp to Week 12

    Measured from Urine Sample

  • Creatinine LevelsUp to Week 12

    Measured from Urine Sample