Study of HMB-enriched Amino Acid Supplementation for Alcoholic Liver Disease and COVID-19

This study is looking at how a dietary supplement called β-hydroxy β-methyl butyrate (HMB) might help people who have both alcoholic liver disease (ALD) and COVID-19 pneumonia. HMB is a substance that can help build muscle. Researchers want to see if HMB can prevent breathing problems and improve recovery for these patients. You might be able to join if you are 21 or older, have ALD (diagnosed by clinical, imaging, lab, or biopsy results) and COVID-19 pneumonia, and meet specific liver health criteria (Child Pugh score 5-8, serum creatinine <3, MELD score <25). The study will measure changes in muscle mass and the number of hospital admissions over 90 days to see if the supplement is helpful. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 48 participants. It compares a dietary supplement called β-hydroxy β-methyl butyrate (HMB) enriched amino acid with a balanced amino acid supplement.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 90 days after starting the study to measure changes in muscle mass and hospital admissions.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04858412

Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19

Recruiting
NAAges 21+InterventionalBasic science
The Cleveland Clinic
~48 participants
Updated 2025-11-25 on ClinicalTrials.gov
What's tested:β-hydroxy β-methyl butyrate (HMB) enriched amino acidBalanced amino acid

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in skeletal muscle mass at Day 0 and Day 90
Measured over Baseline and Day 90
+1 more outcome measured
Alcoholic Liver Disease
COVID 19 Pneumonia
1 sites across 1 states
Ohio1
  • Srinivasan Dasarathy, MD · PRINCIPAL_INVESTIGATOR · Staff

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  • Change in skeletal muscle mass at Day 0 and Day 90Baseline and Day 90
  • Number of hospital admissions between Day 0 and Day 90Baseline and Day 90