Back to search results

Gabapentin for Pain After Wisdom Teeth Removal

This study is looking at whether taking gabapentin 600mg before wisdom teeth removal can help reduce the amount of opioid pain medication you need afterward. Researchers will compare gabapentin to a placebo (a pill that looks like gabapentin but has no medicine in it). They want to see if gabapentin can provide good pain control while lowering opioid use. You could be eligible if you are between 18 and 59 years old, have a BMI between 18-35, and are generally healthy (ASA Class I or II). The study aims to enroll 98 participants, but its current status is unclear.

Study design
This is a double-blind, randomized study where 98 participants will either receive gabapentin or a placebo before wisdom teeth extraction.
What's involved
You would take a pill (gabapentin or placebo) 2 hours before your wisdom teeth removal. Researchers will then measure your pain and opioid use at several times over 72 hours after the procedure.
Compensation
Not stated in the trial record.
Follow-up
Your opioid use, pain, and side effects will be measured at 4, 8, 12, 24, and 72 hours after the procedure.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04860141

Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.

Recruiting
PHASE4Ages 18–59InterventionalPrevention
Loma Linda University
~98 participants
Updated 2026-02-04 on ClinicalTrials.gov
What's tested:Gabapentin 600mgPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
opioid use
Measured over 4 hour postoperatively
+5 more outcomes measured

Conditions

Dental Pain and Sensation Disorder
Pain, Postoperative

Explore related trials

Central pain

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Chi Viet, DDS MD PhD · PRINCIPAL_INVESTIGATOR · Loma Linda University

Who to contact

Je Dong Ryu, DMD MD
[email protected]
909-558-4423
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Subjects must be at or older than 18.
Screened body mass index (BMI) between 18-35 kg/m2.
American Society of Anesthesiologists Classification I and II.
Subjects must be willing and able to comply with protocol requirements.
Subjects must be able to understand the informed consent and must be able to sign a written informed consent form prior to the initiation of any study procedures.
A subject must have at least 1 partial or fully impacted third molar tooth removal.

Exclusion

hypersensitivity to gabapentinoids;
history of chronic opioid or gabapentin usage (regular use of opioids \>3 months)
history of recreational drug usage
a history or clinical manifestations of significant metabolic, hematologic, pulmonary, cardiovascular, gastrointestinal, neurologic, hepatic, renal, urologic, musculoskeletal, psychiatric, or immunologic disorder, any acute, clinically significant illness or condition within 14 days prior to Day 1.
Patients with baseline pain.
Patients with any oral pathology will be excluded.
Pregnant or breastfeeding patients
An individual not legally competent to consent (e.g., incapacitated individuals, incompetents, minors)

What this trial measures

  • opioid use4 hour postoperatively

    assess the number of opioid pills (norco 5/325mg) taken postoperatively. #of pills that a patient takes.

  • opioid use8 hour postoperatively

    assess the number of opioid pills (norco 5/325mg) taken postoperatively. #of pills that a patient takes.

  • opioid use12 hour postoperatively

    assess the number of opioid pills (norco 5/325mg) taken postoperatively. #of pills that a patient takes.

  • opioid use48 hour postoperatively

    assess the number of opioid pills (norco 5/325mg) taken postoperatively. #of pills that a patient takes.

  • opioid use72 hour postoperatively

    assess the number of opioid pills (norco 5/325mg) taken postoperatively. #of pills that a patient takes.

  • intraoperative fentanyl useduring the surgical procedure

    assess amount of fentanyl given intraoperatively. mcg of fentanyl given in a case.