Metabolic Profiling of Immune Responses in Immune-mediated Diseases
This study aims to understand how your immune system and skin healing are connected. Researchers want to learn more about conditions like primary immunodeficiency (when your immune system doesn't work properly), psoriasis, and atopic dermatitis (eczema). They are looking for changes in skin microbes (germs on your skin) and substances in your skin that are linked to wound healing or immune problems. They also want to see how metabolic pathways (the chemical processes in your body) are related to immune responses and wound healing. This study is observational, meaning no specific interventions are being tested. It is open to people aged 18 to 75 with these conditions, as well as healthy volunteers. The study's status is currently unclear.
- Study design
- This is an observational study aiming to enroll 300 participants, including healthy volunteers and those with immune-mediated diseases.
- What's involved
- You will have a medical history review, physical exam, and potentially a pregnancy test. You may also have blood draws, skin biopsies (up to four), skin swabs, and tape strips collected.
- Compensation
- Not stated in the trial record.
- Follow-up
- Measurements will be taken throughout the study, but a specific follow-up duration is not mentioned.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Metabolic Profiling of Immune Responses in Immune-mediated Diseases
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Ian A Myles, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Allergy and Infectious Diseases (NIAID)
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Change in relative abundance of microbial skin taxa and/or skin metabolites associated with wound healing or immune mediated disorders.Throughout study
Determine whether there are abnormalities in specific tissue repair pathways, such as epithelial to mesenchymal transition (EMT) are associated with immune-mediated disorders.
- Fold difference in metabolic pathways associated with immune pathways.Throughout study
Evaluate metabolic profiles in immune activation associated with known or suspected immune-mediated disorders.
- Fold differences in metabolic pathways related to wound healing.Throughout study
Determine whether there are abnormalities in specific tissue repair pathways, such as epithelial to mesenchymal transition (EMT) are associated with immune-mediated disorders.