Dietary Intervention for Night Work Health
This study is testing a dietary intervention to see if it can help reduce the negative health effects of night shift work. Researchers want to understand if changing what you eat can lessen problems like an increased risk for diabetes that can come from working at night. They will look at how your body handles sugar (glucose tolerance) and changes in the tiny living things in your mouth and gut (oral and gut microbiome). You may be able to join if you are between 18 and 45 years old, have a body mass index (BMI) between 20.0 and 29.9, and are of European, Hispanic, or African-American ancestry. You should not have any serious medical conditions, a history of smoking/vaping for 5 or more years, or a history of drug/alcohol dependency or psychiatric illness. The study aims to enroll 24 participants, but its current status is unclear.
- Study design
- This is an interventional study, meaning participants will receive a specific dietary intervention. It plans to enroll 24 participants.
- What's involved
- You would complete two inpatient stays, be provided with identical meals, have frequent blood draws, and provide urine, saliva, stool, and rectal swab samples.
- Compensation
- Not stated in the trial record.
- Follow-up
- Changes in glucose tolerance and microbial communities will be measured from Baseline (Day 2) to Test Day (Day 4).
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Dietary Intervention to Mitigate Adverse Consequences of Night Work
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Frank Scheer, PhD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Change in glucose tolerance from Baseline to Test DayBaseline (Day 2) and Test Day (Day 4)
Change in incremental glucose area under the curve (AUC) from a mixed meal test.
- Changes in microbial community structure/composition/function of oral and gut microbiome from Baseline to Test DayBaseline (Day 2) and Test Day (Day 4)
Shotgun metagenomics sequencing or 16S rRNA sequencing of saliva, stool, and rectal swab samples will provide in-depth interrogation of the microbial community structure, composition, and function.