Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout

This study is comparing two common ways to manage gout: one aims to lower your uric acid levels (using allopurinol, naproxen, and colchicine) to a specific target, and the other focuses on treating symptoms as they arise. Researchers want to see which approach is better for people with gout. You might be eligible if you are 18 to 90 years old, have a confirmed diagnosis of gout, and are a patient at a participating primary care practice. The study will measure how often gout flares happen over two years to see which treatment strategy is more effective. The current recruitment status is unclear.

Study design
This is a randomized, controlled multicenter study planning to enroll 650 participants. It compares two treatment strategies for gout.
What's involved
Participants in the 'treat-to-target' group will have blood draws every 4 weeks until their uric acid target is reached. The study will follow participants for two years.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for two years after starting the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04875702

Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout

Recruiting
PHASE4Ages 18–90InterventionalTreatment
Massachusetts General Hospital
~650 participants
Updated 2025-09-25 on ClinicalTrials.gov
What's tested:AllopurinolNaproxen 250 MGColchicine 0.6 mgColchicine 1.2 mgNaproxen 500 MgPrednisone 40 mg

At a glance

Recruiting sites
3 of 7 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Frequency of gout flare
Measured over baseline to two years of follow up
Gout
7 sites across 5 states
Massachusetts3
Alabama1
California1
New York1
West Virginia1
  • Hyon K Choi, MD, PhD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital

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  • Frequency of gout flarebaseline to two years of follow up

    number of gout flares occurring during two years of follow-up between the TTT-SU and TTASx groups