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Neurofeedback for Reading Difficulties After Stroke

This study is testing a new approach called Motor Imagery and Real-Time fMRI Neurofeedback to help people who have trouble reading after a stroke. This method uses a special type of brain scan (fMRI) to show you your brain activity in real-time while you imagine moving your right hand. The goal is to help your brain shift activity back to the left side, which is important for language. You might also be in a group that uses Motor Imagery and Sham fMRI Neurofeedback, which is a comparison group. This study is for people aged 18-80 who have had a stroke affecting the left side of their brain within the last 10 weeks and have reading difficulties, or healthy volunteers. Researchers will measure how accurately you read aloud and changes in your brain activity to see if the treatment is successful. The study is planning to enroll 28 participants, but its current status is unclear.

Study design
This is an interventional study comparing two types of neurofeedback. It plans to enroll 28 participants.
What's involved
Participants will perform motor imagery tasks and complete three sessions of motor imagery and reading tasks.
Compensation
Not stated in the trial record.
Follow-up
Reading accuracy and fMRI brain activity will be measured at the end of weeks 1, 2, and 3 of the intervention.

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NCT04875936

Neurofeedback Intervention for Reading Deficits in Subacute Stroke

Recruiting
NAAges 18–80InterventionalTreatment
Kessler Foundation
~28 participants
Updated 2026-05-08 on ClinicalTrials.gov
What's tested:Motor Imagery and Real-Time fMRI NeurofeedbackMotor Imagery and Sham fMRI Neurofeedback

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Reading Aloud Accuracy
Measured over change from baseline at intervention week 1, 2, and 3
+1 more outcome measured

Conditions

Stroke
Dyslexia, Acquired

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DyslexiaHealthy VolunteerStroke

Where it's being run

1 sites across 1 states
New Jersey1

Who to contact

Olga Boukrina, Ph.D.
[email protected]
9733243587
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

First-ever left-hemisphere stroke \< 3 months prior to study recruitment or healthy volunteer
Age: 18 - 80 years old
Fluent and literate in English prior to stroke
Reading deficits, defined as \>3 errors on the Paragraphs test (subtests VIII, IX) of the Reading Comprehension Battery for Aphasia-2nd ed. (RCBA-2) in keeping with the healthy control accuracy criterion of 86-100% correct.

Exclusion

Inability to consent or complete study tasks
Inability to undergo MRI (e.g., pregnancy, non-MRI compatible implants, claustrophobia)
A history of prior neurological disease (e.g., brain tumor, Alzheimer's disease)

What this trial measures

  • Reading Aloud Accuracychange from baseline at intervention week 1, 2, and 3

    Read aloud 136 words to produce an accuracy score in percent correct.

  • fMRI Brain Activitychange from baseline at intervention week 1, 2, and 3

    Whole-brain and region of interest activation and resting state functional connectivity