Twin Block, Pain Medications and Third Molar Extractions

This study is looking at ways to manage pain after wisdom tooth removal without relying heavily on opioid medications. Researchers are testing a local anesthetic nerve block called the Twin Block, which uses 2% lidocaine with 1:100,000 epinephrine (a common dental anesthetic). They will compare this to a placebo (sterile normal saline) given through the same Twin Block injection. The goal is to see if the Twin Block can reduce muscle pain after the procedure, lower overall pain scores, and decrease the amount of opioid pain medication you might need. You could be eligible if you are over 18, healthy, and need at least one lower wisdom tooth removed under sedation. The study aims to enroll 48 participants.

Study design
This interventional study plans to enroll 48 participants to compare the Twin Block local anesthetic with a placebo.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your pain will be measured 15 minutes after the injection and again one week later. Total opioid consumption will also be tracked for one week.

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NCT04880707

Twin Block, Pain Medications and Third Molar Extractions

Recruiting
PHASE2Ages 18+InterventionalSupportive care
Rutgers, The State University of New Jersey
~48 participants
Updated 2026-06-22 on ClinicalTrials.gov
What's tested:Twin block local anesthetic nerve block using standard dental anestheticTwin block with placebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Post-injection muscle pain
Measured over 15 minutes
+2 more outcomes measured
Acute Pain
1 sites across 1 states
New Jersey1
  • Gayathri Subramanian, PhD, DMD · PRINCIPAL_INVESTIGATOR · Rutgers School of Dental Medicine, Newark NJ

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Eligibility criteria

Inclusion

All patients requiring extraction/s of at least 1 lower wisdom (third) molar that is partially/fully 'impacted', under intravenous sedation, are eligible to participate in this study so long as they

Exclusion

Any patients, even if satisfying the criteria above, may not take part if they have any of the following:
  • Post-injection muscle pain15 minutes

    NRS pain scores before and 15 min after Twin block administration on day after procedure

  • Mean NRS pain scoreone week

    Means NRS pain score by Day, comparing placebo and Twin block groups

  • Total prescription opioid consumptionone week

    Comparison of total prescription opioid consumption (mg) between placebo and Twin block groups