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Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery

{ "Minimally Invasive Surgery for Complex Adult Spinal Deformity", "This study is observing adults with complex spinal deformities like scoliosis (a sideways curve of the spine) or kyphosis (a forward rounding of the back). Researchers want to understand how well minimally invasive surgery works for these conditions. They will look at your quality of life and ability to do daily activities using questionnaires like the Scoliosis Research Society (SRS) 22r and Oswestry Disability Index (ODI). The study aims to find the best ways to treat these conditions, reduce complications, and improve patient outcomes. You may be able to join if you are over 18, have a diagnosis of adult spinal deformity, and are scheduled for surgery within six months.", "design": "This is an observational study, meaning researchers will watch and collect information about 500 participants undergoing surgery. It is not testing a new treatment but rather observing current surgical practices.", "commitments": "You will have your surgery as planned by your surgeon. Researchers will collect information from you at 3 months, 1 year, 2 years, 5 years, and 10 years after your surgery.", "compensation": "Not stated in the trial record.", "follow_up": "Participants will be followed for up to 10 years after their surgery to assess long-term outcomes.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04885244

Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery

Recruiting
Not specifiedAges 18+Observational
International Spine Study Group Foundation
~500 participants
Updated 2026-02-17 on ClinicalTrials.gov
What's tested:Index or spine revision surgery for complex adult spinal deformity

At a glance

Recruiting sites
11 of 12 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Scoliosis Research Society (SRS) 22r
Measured over Change from Preop to 3 months and 1, 2, 5 & 10 year follow-up
+11 more outcomes measured

Conditions

Adult Spinal Deformity
Scoliosis
Kyphosis
Sagittal Imbalance

Explore related trials

Spinal Deformity

Where it's being run

12 sites across 10 states
California3
Arizona1
Florida1
Illinois1
Louisiana1
Michigan1
New York1
North Carolina1

Study leadership

  • Praveen Mummaneni, MD · PRINCIPAL_INVESTIGATOR · University of San Francisco
  • Paul Park, MD · PRINCIPAL_INVESTIGATOR · Semmes-Murphey Clinic
  • Gregory Mundis, MD · PRINCIPAL_INVESTIGATOR · Scripps Clinic, Department of Orthopedic Surgery, La Jolla, CA
  • Juan Uribe, MD · PRINCIPAL_INVESTIGATOR · Barrow Neurological Institute, Phoenix, AZ

Who to contact

Christine Baldus, MS
[email protected]
6184444130
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

What this trial measures

  • Scoliosis Research Society (SRS) 22rChange from Preop to 3 months and 1, 2, 5 & 10 year follow-up

    Scoliosis specific patient reported outcome

  • Oswestry Disability Index (ODI)Change from Preop to 3 months and 1, 2, 5 & 10 year follow-up

    Spine specific patient reported outcome

  • Veterans RAND 12 Item Health Survey (VR-12)Change from Preop to 3 months and 1, 2, 5 & 10 year follow-up

    Patient reported outcome

  • Patient-Reported Outcome Measurement Information System (PROMIS) - AnxietyChange from Preop to 3 months and 1, 2, 5 & 10 year follow-up

    Computer adaptive Patient reported outcome

  • Patient-Reported Outcome Measurement Information System (PROMIS) - DepressionChange from Preop to 3 months and 1, 2, 5 & 10 year follow-up

    Computer adaptive Patient reported outcome

  • Patient-Reported Outcome Measurement Information System (PROMIS) - Pain InterferenceChange from Preop to 3 months and 1, 2, 5 & 10 year follow-up

    Computer adaptive Patient reported outcome

  • Patient-Reported Outcome Measurement Information System (PROMIS) - Physical FunctionChange from Preop to 3 months and 1, 2, 5 & 10 year follow-up

    Computer adaptive Patient reported outcome

  • Patient-Reported Outcome Measurement Information System (PROMIS) - Social SatisfactionChange from Preop to 3 months and 1, 2, 5 & 10 year follow-up

    Computer adaptive Patient reported outcome

  • Patient-Reported Outcome Measurement Information System (PROMIS) - Social Role SatisfactionChange from Preop to 3 months and 1, 2, 5 & 10 year follow-up

    Computer adaptive Patient reported outcome

  • Radiographic EvaluationChange from Preop to 3 months and 1, 2, 5 & 10 year follow-up

    Cobb angles, Coronal \& Sagittal balance, spinopelvic measures

  • Visual Analog Scale - Back PainChange from Preop to 3 months and 1, 2, 5 & 10 year follow-up

    Self-reported back pain on scale of 0 (No pain) to 10 (severe pain)

  • Visual Analog Scale - Leg painChange from Preop to 3 months and 1, 2, 5 & 10 year follow-up

    Self-reported leg pain on scale of 0 (No pain) to 10 (severe pain)