Time-Restricted Feeding for Metabolic Health in Postmenopausal Women

This study is looking at whether time-restricted feeding (TRF) can improve metabolic health in postmenopausal women who are prediabetic or have features of metabolic syndrome. TRF involves eating all your daily food within a specific 10-hour window. Researchers will compare women who practice TRF to those who don't, over 18 weeks. They will measure changes in insulin sensitivity (how well your body uses insulin), Body Mass Index (BMI), and triglycerides (a type of fat in your blood). You may be able to join if you are a postmenopausal woman between 45 and 65 years old with certain metabolic health concerns. The current status of this study is unclear.

Study design
This is a randomized study with two groups, aiming to enroll 164 participants. Participants will either follow time-restricted feeding or not.
What's involved
You would provide baseline information for two weeks, then follow your assigned group for 16 weeks. You would text the times of your first and last daily meals.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be collected at 18 weeks (baseline and post-intervention).

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NCT04893226

Circadian Rhythms in Postmenopausal Women

Recruiting
NAAges 45–65InterventionalPrevention
Julie Pendergast
~164 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:Time-Restricted Feeding (TRF)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Insulin Sensitivity
Measured over 18 weeks (baseline and post-intervention)
+2 more outcomes measured
Metabolic Syndrome
Postmenopausal Symptoms
1 sites across 1 states
Kentucky1
  • Julie S Pendergast, PhD · PRINCIPAL_INVESTIGATOR · University of Kentucky

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Eligibility criteria

Inclusion

postmenopausal women
age 45-65 years
prediabetic or have at least 2 features of metabolic syndrome

Exclusion

on hormone therapy
diabetes
heart disease
alcohol consumption of \>2 drinks per day
significant circadian disruption
having care-taking responsibilities that significantly affect sleep
shift work or irregular lifestyle
uncontrolled sleep apnea or other uncontrolled sleep disorder
extreme early or late chronotypes
significant psychiatric disorders
taking ADHD medications
diagnosed dysregulated eating behaviors
smoking \>5 cigarettes/day or 30 pack-year history
participating in formal weight loss program
not weight stable
  • Change in Insulin Sensitivity18 weeks (baseline and post-intervention)

    Matsuda index will be assessed by the oral glucose tolerance test (OGTT).

  • Change in Body Mass Index18 weeks (baseline and post-intervention)

    Body mass index will be calculated from height and weight.

  • Change in Triglycerides18 weeks (baseline and post-intervention)

    Triglycerides will be measured from fasting blood