This study is looking at how people with chronic constipation (difficulty having bowel movements) experience defecation. Researchers want to understand the natural process of bowel movements better, as current tests don't fully explain why some people have constipation. You could be eligible if you are between 21 and 75 years old. The study will involve two groups: healthy individuals with normal bowel movements and patients with chronic constipation due to outlet obstruction (a type of constipation where there's a problem with the muscles or nerves that help stool leave the body). Researchers will use a special device called Fecobionics, which is like a simulated stool, to measure what happens in the rectum during defecation. They will also study the effects of two medications: Bisacodyl, a stimulant laxative expected to help with bowel movements, and Atropine, which is expected to make bowel movements more difficult. The main goal is to measure how long it takes to expel a rectal balloon. The current status of this study is unclear.

Study design

This is an interventional study with a planned enrollment of 130 participants. It will include both healthy individuals and patients with chronic constipation.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint, evacuation duration of a rectal balloon, will be measured at 3 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.