Extension Study of Inhaled Treprostinil for Fibrotic Lung Disease

This study is looking at the long-term safety and how well inhaled treprostinil works for people with Idiopathic Pulmonary Fibrosis (IPF) or Progressive Pulmonary Fibrosis (PPF). Inhaled treprostinil is a drug delivered as a mist you breathe in, using a special device. To join this study, you must have already participated in one of three specific previous studies (RIN-PF-301, RIN-PF-303, or RIN-PF-305). Researchers will be monitoring your health and lung function over time to see if the treatment is safe and tolerable. The study is currently unclear on its recruitment status and plans to enroll up to 1850 participants.

Study design
This is a Phase 3, multicenter, open-label extension study. It is designed for participants who completed previous studies.
What's involved
You would return for visits at Week 4, Week 12, and then every 12 weeks for up to 6 years. These visits will include tests like spirometry (a breathing test) and monitoring for side effects.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 6 years to assess long-term safety and tolerability.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04905693

Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

Enrolling by Invitation
PHASE3Ages 40+InterventionalTreatment
United Therapeutics
~1,850 participants
Updated 2026-07-28 on ClinicalTrials.gov
What's tested:Inhaled TreprostinilTreprostinil Ultrasonic Nebulizer

At a glance

Recruiting sites
0 of 192 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Long-term safety and tolerability of inhaled treprostinil in subjects with IPF or PPF
Measured over Baseline to 6 years
Idiopathic Pulmonary Fibrosis
Interstitial Lung Disease
Progressive Pulmonary Fibrosis
192 sites across 102 states
Texas9
Florida8
California7
France6
New York5
Arizona4
North Carolina4
Pennsylvania4

This trial hasn't published a contact. View it on ClinicalTrials.gov

  • Long-term safety and tolerability of inhaled treprostinil in subjects with IPF or PPFBaseline to 6 years

    Incidence of AEs and SAEs, incidence of abnormal clinical laboratory parameters, abnormal vital signs, and abnormal 12-lead ECGs