Understanding Thinking and Memory Changes After Stroke (DISCOVERY Study)

The DISCOVERY study aims to understand why some people experience changes in their thinking and memory (cognitive abilities) after a stroke. Researchers want to identify factors that contribute to post-stroke cognitive impairment and dementia (a decline in memory and thinking that affects daily life). This study is observing 8,000 patients who have had an ischemic stroke (blood clot in the brain), intracerebral hemorrhage (bleeding in the brain), or aneurysmal subarachnoid hemorrhage (bleeding around the brain). The main goal is to see how a person's diagnosis of post-stroke cognitive impairment and dementia changes over 48 months. This information could help doctors better identify patients at risk and develop future treatments.

Study design
This is an observational study involving 8,000 participants. It is designed to look at a large group of people over time.
What's involved
You would have a blood draw and complete thinking and memory tests at the start. You would also have in-person follow-up visits at 3-6 months and 18 months, and annual phone calls for the study's duration.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 48 months after their stroke to assess changes in thinking and memory.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04916210

Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

Recruiting
Not specifiedAges 18+Observational
Massachusetts General Hospital
~8,000 participants
Updated 2025-11-03 on ClinicalTrials.gov

At a glance

Recruiting sites
28 of 31 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in post-stroke cognitive impairment and dementia (PSCID) diagnosis status
Measured over Baseline to 48 months post-index stroke
Ischemic Stroke
Intracerebral Hemorrhage
Subarachnoid Hemorrhage
Dementia, Vascular
Mild Cognitive Impairment
Vascular Cognitive Impairment
31 sites across 21 states
California4
Texas3
Florida2
Massachusetts2
Minnesota2
New York2
North Carolina2
Arizona1
  • Natalia Rost, MD, MPH · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital
  • Steven Greenberg, MD, PhD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital

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  • Change in post-stroke cognitive impairment and dementia (PSCID) diagnosis statusBaseline to 48 months post-index stroke