Early Feasibility Study of the INNOVALVE System for Mitral Valve Regurgitation

This study is testing a new device called the INNOVALVE system for people with mitral valve regurgitation (a condition where the heart's mitral valve doesn't close properly, causing blood to leak backward). You might be able to join if you have significant symptoms from this condition, are considered high-risk for open-heart surgery, and meet specific anatomical requirements. The main goal of this study is to see if the INNOVALVE system can be safely implanted without serious problems within 30 days. This is an early study, and the current recruitment status is unclear, with a plan to enroll about 65 participants.

Study design
This is a First-In-Human, multi-center, prospective, single-arm study designed to evaluate the safety and performance of the INNOVALVE system. It plans to enroll about 65 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary safety endpoint is measured at 30 days after the implant or delivery.

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NCT04919980

TVMR With the INNOVALVE System Trial - Early Feasibility Study

Recruiting
NAAges 18+InterventionalTreatment
Edwards Lifesciences
~65 participants
Updated 2026-05-28 on ClinicalTrials.gov
What's tested:INNOVALVE system

At a glance

Recruiting sites
19 of 20 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Absence of implant or delivery related serious adverse events at 30 Days
Measured over 30 days
Mitral Valve Regurgitation (Degenerative or Functional)
20 sites across 14 states
New York3
California2
Georgia2
Ohio2
Tennessee2
Florida1
Illinois1
Michigan1
  • Chet Rihal · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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Eligibility criteria

Inclusion

Clinically significant, symptomatic mitral regurgitation
High risk for open-heart surgery
Meets anatomical criteria

Exclusion

Unsuitable anatomy
Patient is inoperable
EF\<25%
  • Absence of implant or delivery related serious adverse events at 30 Days30 days

    Absence of implant or delivery related serious adverse events