This research study is looking at how childhood trauma and stress might be connected to depression and the risk of suicide. Researchers want to see how both short-term and long-term stress affect tiny genetic materials called microRNAs (miRNAs) in your body. miRNAs are very small and respond to your environment, so they might show how stress affects you. You can join if you are 18-60 years old, physically healthy, and have either a diagnosis of Major Depressive Disorder (MDD) or no history of mental illness. The study will measure your microRNA response to stress 24 hours after a stress test. The current recruitment status is unclear.

Study design

This is an observational study planning to enroll 450 participants. It is not specified if the study is randomized or blinded.

What's involved

You will undergo a Trier Social Stress Test (TSST), which involves abstaining from caffeine and nicotine, and having an IV placed. Your microRNA response will be measured 24 hours later.

Compensation

Not stated in the trial record.

Follow-up

MicroRNA response to stress will be measured at 24 hours.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.