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Optimizing Incentives for Opioid and Cocaine Abstinence

This study is exploring ways to help people with opioid-use disorder or cocaine-use disorder stay abstinent. It's testing an app-based program called "App-Based Contingency Management" where you can earn financial rewards for submitting drug-negative saliva tests. Another group will use the app without financial incentives (Sham Control). Researchers want to see how well these approaches work to encourage abstinence and how acceptable the app is to users. You could be eligible if you are at least 18 years old, have a diagnosis of opioid or cocaine use disorder, and have a smartphone. The study aims to enroll 600 participants.

Study design
This interventional study plans to enroll 600 participants to compare two behavioral interventions: App-Based Contingency Management and Sham Control.
What's involved
Participants will submit randomly generated drug-negative saliva tests throughout the intervention period. App acceptability will be measured at month 12.
Compensation
Participants in the App-Based Contingency Management group will receive financial incentives.
Follow-up
The study measures the percent of negative saliva tests at month 3 and app acceptability at month 12.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04927143

Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

Recruiting
NAAges 18+InterventionalSupportive care
Wake Forest University Health Sciences
~600 participants
Updated 2026-02-12 on ClinicalTrials.gov
What's tested:App-Based Contingency ManagementSham Control

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent of Negative Saliva Tests
Measured over month 3
+1 more outcome measured

Conditions

Opioid-use Disorder
Cocaine Use Disorder
Opioid Use
Cocaine Use
Substance Use
Methamphetamine Abuse
Methamphetamine-dependence

Explore related trials

Amphetamine-induced organic mental disorderCocaine Use DisorderOpioid Use Disorder

NCT04927143

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Advocate Aurora Behavioral Health Services

    Wauwatosa, Wisconsinstudy coordinator listed

    Recruiting

  • Rogers Behavioral Health

    Oconomowoc, Wisconsinno site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Mercedes Robaina, PhD · PRINCIPAL_INVESTIGATOR · Advocate Aurora Behavioral Health Services
  • Ariel Zucker, PhD · STUDY_DIRECTOR · University of California Santa Cruz

Who to contact

Kevin Petranu
[email protected]
414-293-9736
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Age at least 18 years old;
Meet DSM-5 OUD, CoUD, or MUD criteria as evidenced by an OUD CPT code F11\* (opioid related disorders), a CoUD CPT code F14\* (cocaine related disorders), a MUD CPT code F15.1/F15.2 or other clinical notes indicating illicit opioid/cocaine/methamphetamine use for treatment
Have access to a smartphone (iOS or Android) with data plan and willing to download DynamiCare app;
Have an email and can access it from their smartphone;
Are in residential, day (PHP), partial day (IOP), or outpatient (OP) AODA treatment;
Are likely to be helped by contingency management because at least ONE of the following conditions is true:
Understands English.

Exclusion

Have evidence of active (non-substance related) psychosis that might impair participation as determined by the PI.
Has significant cognitive impairment that might confound participation as determined by the PI or are so significantly cognitively impaired that they have a legal guardian.

What this trial measures

  • Percent of Negative Saliva Testsmonth 3

    Percent of tests negative for non-medical opioids, cocaine, or stimulant

  • Percent of App Acceptabilitymonth 12

    Percent of eligible population which accepts app