Ketamine Infusion for Neuropathic Pain in Brachial Plexus Injuries

This study is looking into whether an intravenous (IV) infusion of ketamine during and after surgery can help reduce neuropathic pain in people who have had a brachial plexus injury. Neuropathic pain is pain caused by nerve damage. You might be able to join if you have neuropathic pain from a traumatic brachial plexus injury that requires surgery, and your pain level is above 4 out of 10. The study will measure changes in your neuropathic pain score at the start and one week after surgery to see if the ketamine infusion is effective. The current status of this study is unclear, and it plans to enroll 100 participants.

Study design: This is an interventional study planning to enroll 100 participants. It will assess the effect of ketamine infusion on neuropathic pain.
What's involved: You would receive a ketamine infusion during your brachial plexus reconstruction surgery and a lower dose infusion after surgery. Your neuropathic pain will be measured at the start of the study and one week later.
Compensation: Not stated in the trial record.
Follow-up: Your pain will be assessed at baseline and one week after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Ketamine Infusion for Neuropathic Pain in Brachial Plexus Injuries

Enrolling by Invitation

PHASE4Ages 18+InterventionalTreatment

Mayo Clinic

~100 participants

Updated 2026-04-24 on ClinicalTrials.gov

What's tested:Ketamine Infustion

At a glance

Recruiting sites

0 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Change in PROMIS Pain Quality - Neuropathic Pain (PQ-Neuro) score

Measured over Baseline, 1 week

Conditions

Brachial Plexus Injury

Where it's being run

1 sites across 1 states

Minnesota1

Study leadership

Alexander Shin, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients with neuropathic pain associated with avulsion injuries following traumatic brachial plexus injuries scheduled for brachial plexus exploration and reconstruction by three senior surgeons at Mayo Clinic (AYS, ATB, RJS):

Neuropathic pain defined as pain directly related to injury to the somatosensory system, and score \>4/10 on the Douleur Neuropathique en 4 Questions (DN4) neuropathic pain questionnaire. Symptoms of neuropathic pain include allodynia, hyperalgesia, burning, needle-like, throbbing, shooting, or electrical-type sensation.

Nerve root avulsion on CT myelogram.

Traumatic brachial plexus injuries defined as blunt or penetrating trauma resulting in injury and dysfunction along the course of the brachial plexus defined as nerve roots C5-T1, trunks, divisions, cords, and terminal branches.

Exclusion

Patients without pain following traumatic brachial plexus injuries.

Patients with brachial plexus injuries due to non-traumatic causes such as tumors, infection, radiation, or inflammatory disorders such as Parsonage Turner Syndrome.

Patients who do not require surgery for exploration/reconstruction at the brachial plexus.

Patients under 18 years of age.

Contraindication to ketamine use (severe hepatic dysfunction -cirrhosis, high-risk coronary artery disease, poorly controlled psychiatric condition- schizophrenia.

What this trial measures

Change in PROMIS Pain Quality - Neuropathic Pain (PQ-Neuro) scoreBaseline, 1 week
Measured by the PROMIS Pain Quality - Neuropathic Pain (PQ-Neuro) self-reported questionnaire asking about pain in the past 7 days using a scale of 1=not at all and 5=very much. Higher scores indicate a worse outcome.

Trialytics