The GUARDIAN Trial - Induction Agent Sub-Study for Major Surgery
This study is looking at different ways to manage blood pressure and anesthesia during major surgery. It's a sub-study of a larger trial, and it specifically compares two anesthetic medications: etomidate and propofol. Researchers want to see if one of these medications, when used for anesthesia induction (the start of anesthesia), leads to fewer major complications related to blood flow after surgery. You might be able to join if you are at least 45 years old, scheduled for major non-heart surgery expected to last at least two hours, and will have general or neuraxial anesthesia. The study aims to enroll 6254 participants, but its current status is unclear.
- Study design
- This interventional study involves participants being randomly assigned to receive either etomidate or propofol for anesthesia induction, in addition to different blood pressure management strategies. It plans to enroll 6254 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 30 days after major non-cardiac surgery to check for major perfusion-related complications.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
The GUARDIAN Trial - Induction Agent Sub-Study
At a glance
Conditions
Where it's being run
11 sites across 6 statesStudy leadership
- Daniel I Sessler, MD · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center, Houston
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
What this trial measures
- Number of Participants with a Composite of Major Perfusion-Related ComplicationsDuring the initial 30 days after major non-cardiac surgery
The primary outcome is a composite of major perfusion-related complications (myocardial injury, stroke, non-fatal cardiac arrest, Stage 2-3 acute kidney injury, deep or organ-space infection, sepsis, and death) in the 30 days after major non-cardiac surgery.