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Transcranial Magnetic Stimulation (TMS) Study for Adults With Autism Spectrum Disorder (ASD)

This study is looking at how Transcranial Magnetic Stimulation (TMS) affects the brain and social behaviors in adults with Autism Spectrum Disorder (ASD). Researchers want to see if TMS can improve how the brain responds to faces. You might be able to join if you are between 18 and 40 years old, with or without an ASD diagnosis, and can participate in EEG (electroencephalogram, which measures brain waves) and eye-tracking experiments. The study will measure changes in brain activity (specifically, right hemisphere N170 latency) and how much attention you pay to people's eyes. The current recruitment status is unclear.

Study design
This is an interventional study where about 60 participants will receive both active and sham (inactive) TMS in a randomized crossover assignment.
What's involved
You will have two study visits, each lasting about 4-5 hours. These visits will include baseline assessments, a TMS session, and EEG and eye-tracking to measure brain and visual responses.
Compensation
Not stated in the trial record.
Follow-up
Measures will be recorded during the EEG/ET sessions of participant visits for an expected 1-2 hours.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04936009

Transcranial Magnetic Stimulation (TMS) Study for Adults With Autism Spectrum Disorder (ASD)

Recruiting
NAAges 18–40InterventionalTreatment
Yale University
~60 participants
Updated 2026-02-09 on ClinicalTrials.gov
What's tested:Transcranial Magnetic Stimulation (TMS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
right hemisphere N170 latency
Measured over Measures will be recorded during the EEG/ET sessions of participant visits for an expected 1-2 hours
+1 more outcome measured

Conditions

Autism Spectrum Disorder

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Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Yale University Child Study Center

    New Haven, Connecticutstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • James McPartland, PhD · PRINCIPAL_INVESTIGATOR · Yale University

Who to contact

Nicole Wright, BS
[email protected]
203-785-3488
Email the study team

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Eligibility criteria

Inclusion

Individuals between the ages of 18 and 40 years old with typical development or with a diagnosis of autism spectrum disorder.
Individuals able to participate in an EEG and eye-tracking experiment.

Exclusion

Participants reporting significant head trauma or serious brain illness.
Participants with major psychiatric illness that would preclude completion of study measures.
Participants with a history of serious medical illness, stroke, seizures, epileptiform EEG abnormalities, or family history of seizures.
Participants taking prescription medications that may affect cognitive processes under study.
Participants who have taken alcohol or recreational drugs within the preceding 24 hours.
Females of known/suspected pregnancy or who test positive on a pregnancy test.
Participants with a history of metalworking or injury by shrapnel or metallic objects are also excluded.
Participants with a history of prior TMS therapy or use of an investigational drug within 12 weeks of visit.
Participants with an IQ (intelligence quotient) below 80.

What this trial measures

  • right hemisphere N170 latencyMeasures will be recorded during the EEG/ET sessions of participant visits for an expected 1-2 hours

    EEG brain response to faces as measured by the N170 component in milliseconds

  • proportion of visual attention to the eye region of the faceMeasures will be recorded during the EEG/ET sessions of participant visits for an expected 1-2 hours

    visual attention to the eye region of the face as measured by eye tracking in seconds