Dual Task Perturbation Training for Mild Cognitive Impairment
This study is testing a training program called "Dual Task Perturbation Training" for older adults with mild cognitive impairment (MCI) or those who are cognitively intact. The training involves playing six cognitive games while standing, followed by practicing balance recovery after slips without cognitive tasks. Researchers want to see if this training can improve balance and reduce falls by enhancing how people react to losing their balance. You might be able to join if you are an adult over 55 years old, with or without mild cognitive impairment, and do not have certain other health conditions like stroke or Parkinson's disease. The study aims to measure changes in balance stability and how often people fall in a lab setting. The current recruitment status is unclear.
- Study design
- This interventional study plans to enroll 142 participants. It compares a dual-task training method to a single-task training method.
- What's involved
- Participants will engage in cognitive games while standing, followed by balance training involving slips. The primary endpoints are measured at baseline, immediately after training, and after 4 weeks of training.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study measures changes up to 4 weeks after the training period.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Dual Task Perturbation Training for OAwMCI
At a glance
Conditions
NCT04938349
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Illinois at Chicago
Chicago, Illinoisstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Tanvi Bhatt · PRINCIPAL_INVESTIGATOR · University of Illinois at Chicago
Who to contact
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Inclusion
Exclusion
What this trial measures
- Change in Stability gain or lossBaseline (1st novel slip, trip week 1), immediate post-training (repeated perturbation training session, week 1) and 4 weeks of training
Stability is defined by both the position of a person's center-of-mass (COM) with respect to his or her base-of-support (BOS) and it's velocity.
- Change in Limb support gain or lossBaseline (1st novel slip, trip week 1), immediate post-training (repeated perturbation training session, week 1) and 4 weeks of training
The inability to provide timely limb support due to insufficient amount of upward impulse generated from the ground reactive force can cause limb collapse, as characterized by the quotient of amount and rate of hip descent (Vhip/Zhip) measured from hip height and lead to an eventual fall.
- Change in laboratory-induced fallsBaseline (1st novel slip, trip week 1), immediate post-training (repeated perturbation training session, week 1) and 4 weeks of training
Perturbation is induced successfully and safely to reproduce inadvertent falls in a protective laboratory environment. Falls will be measured by the amount of body weight supported by the full-body harness system and measured by a load cell attached to this system. Instability of the body's COM and poor limb support prior to touchdown of the recovery step account for 90\~100% of subsequent falls (occurring \~500ms later) in both sit-to-stand-slip and in gait-slip, in the laboratory settings. Intervention consists of repeated perturbation training to induce a change in the laboratory induced falls immediately post-training and examine it's retention after the initial training session.
- Change in postural stability during reactive balance control (single and dual-task) on treadmill slipsBaseline (1st novel slip, trip week 1), immediate post-training (repeated perturbation training session, week 1) and 4 weeks of training
Reactive balance control will be examined via the stance perturbation test under single and dual-task conditions (simultaneous performance of Letter number sequencing task or auditory stroop task). Postural stability can be defined as simultaneous control of center of mass (COM) position and velocity during slip-like or trip like perturbation relative to the rear edge of base of support (rear heel). The position is normalized with the individual's foot length, and velocity by square root of gravitational acceleration and individual's body height. Larger values indicate greater stability.
- Change in postural stability during reactive balance control (single and dual-task) on overground slipsBaseline (1st novel slip, trip week 1), immediate post-training (repeated perturbation training session, week 1) and 4 weeks of training
Reactive balance control will be examined via the stance perturbation test under single and dual-task conditions (simultaneous performance of Letter number sequencing task or auditory stroop task). Postural stability can be defined as simultaneous control of center of mass (COM) position and velocity during slip-like or trip like perturbation relative to the rear edge of base of support (rear heel). The position is normalized with the individual's foot length, and velocity by square root of gravitational acceleration and individual's body height. Larger values indicate greater stability.
- Change in walking step lengthBaseline (1st novel slip, trip week 1), immediate post-training (repeated perturbation training session, week 1) and 4 weeks of training
Step length will be determined during single and dual-task walking performance via the walking on the treadmill and the GaitRite mat. Higher values for step length indicate better performance.
- Change in walking cadenceBaseline (1st novel slip, trip week 1), immediate post-training (repeated perturbation training session, week 1) and 4 weeks of training
Cadence will be determined during single and dual-task walking performance via the walking on the treadmill and the GaitRite mat. Lower cadence indicate better performance.
- Change in walking stride lengthBaseline (1st novel slip, trip week 1), immediate post-training (repeated perturbation training session, week 1) and 4 weeks of training
Stride length will be determined during single and dual-task walking performance via the walking on the treadmill and the GaitRite mat. Higher values for stride length indicate better performance.
- Change of accuracy in letter number sequencingBaseline (1st novel slip, trip week 1), immediate post-training (repeated perturbation training session, week 1) and 4 weeks of training
This is an oral trail making test which includes listing alternate letter and number from the cue given in sequence. This test will be performed under single and dual-task conditions. Higher scores indicate better performance.
- Change in accuracy of Visual clock testBaseline (1st novel slip, trip week 1), immediate post-training (repeated perturbation training session, week 1) and 4 weeks of training
This test involves responding to the location of the minute and hour hand on a clock. This test will be performed under single and dual-task conditions. Higher scores indicate better performance.
- Change in dual-task costBaseline (week 1), immediate post-training (repeated perturbation training session, week 1) and 4 weeks of training
Dual-task motor and cognitive cost will be calculated using the formula- \[(Dual-task performance- Single Task performance)/Single task performance\]. This will be calculated for dual-task performance during intentional postural sway, reactive balance control and gait conditions. Lower cost indicates better performance.
- Change in visuomotor taskBaseline (week 1), immediate post-training (repeated perturbation training session, week 1) and 4 weeks of training
This test involves continuous tracking of a cyclic moving target on the screen using a motion sensor placed on the head. Higher scores indicates poor performance.
- Fractional anisotropyBaseline (week 1)
White matter integrity tested using magnetic resonance imaging
- Gray matter volumeBaseline (week 1)
Gray matter volume tested using magnetic resonance imaging
- Functional connectivity Z scoreBaseline (week 1)
Resting state functional connectivity using magnetic resonance imaging