Understanding Social Isolation and Loneliness in Serious Mental Illness
This study is looking into how social isolation and loneliness affect people with serious mental illnesses like psychosis (a condition that affects how your brain processes information) and schizophrenia. Researchers want to understand the brain and behavior (neurobehavioral mechanisms) behind these feelings. You might be able to join if you are 18-55 years old and have experienced a psychotic disorder or mood disorder. You cannot join if you have certain neurological conditions, a recent substance use disorder, or a recent change in medication. The study will use surveys on a smartphone app (EMA) to learn about your feelings and social habits. Success will be measured by understanding changes in social isolation and loneliness, and how these affect daily functioning over 6 months. The study plans to enroll 120 participants, but its current status is unclear.
- Study design
- This interventional study plans to enroll 120 participants. It is not specified if it is randomized or blinded.
- What's involved
- Participants will complete surveys about their feelings and social habits through a smartphone app (EMA). These surveys will be conducted over 6 months.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 6 months to measure social isolation, loneliness, and psychosocial functioning.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Daphne J Holt, MD, PhD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Trait level social isolation and loneliness6 months
UCLA Loneliness Scale(20 and 4 item), Social Network Index, Social Anhedonia Scale, Penn facial affect recognition Task, Social Disconnectedness Scale, Social Provisions Scale
- Characterize within-person, dynamic changes in objective isolation and loneliness6 months
EMA questions derived from the UCLA Loneliness Scales, perceived discrimination scale
- Psychosocial functioning6 months
Quality of Life Scale, Cornblatt Global Functioning - Social and Role Scales
- Physical health and cardiometabolic/immunological panel6 months
Height, weight, waist circumference, systolic and diastolic blood pressure, blood oxygen level, heart rate, interleukin-6, TNF-alpha, Complete metabolic panel, lipid panel, C-reactive protein, Cortisol, CBC, HbA1c