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Ridge Augmentation for Dental Implants

This study is comparing two ways to prepare your jawbone for dental implants if you have bone loss. Researchers are looking at whether using allograft particles (donated bone material) mixed with Recombinant Human Platelet-Derived Growth Factor (rhPDGF) works better than allograft particles mixed with saline (saltwater). Both methods involve covering the graft with a special membrane. The study aims to see how much new bone forms after 4 months. You might be able to join if you are at least 18 years old, speak English, are a patient at UAB Dental School, and need dental implants but have insufficient jawbone width. The study is currently recruiting 44 participants, but its overall status is unclear.

Study design
This is a randomized study where neither the patient nor the examiner knows which treatment is being given. It plans to enroll 44 participants.
What's involved
You will have clinical measurements taken at two time points (grafting and implant placement). You will also have initial and follow-up CT scans and dental X-rays.
Compensation
Not stated in the trial record.
Follow-up
New bone formation will be evaluated 4 months after the grafting procedure.

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NCT04954664

Ridge Augmentation Using Allograft Particles Hydrated With or Without Recombinant Human Platelet-Derived Growth Factor

Recruiting
NAAges 18–99InterventionalTreatment
University of Alabama at Birmingham
~44 participants
Updated 2025-12-29 on ClinicalTrials.gov
What's tested:Allograft particles hydrated with rhPDGFAllograft particles hydrated in a conventional way with saline.

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Quantitative histomorphometric evaluation of new bone formation 4 months after GBR
Measured over From baseline to 4 months

Conditions

Dental Implant
Bone Loss

Explore related trials

Osteopenia

Where it's being run

1 sites across 1 states
Alabama1

Who to contact

Hussein Basma, DDS, MS
[email protected]
205-934-2888
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Eligibility criteria

Inclusion

English speaking
At least 18 years old
Must be a patient of the UAB Dental School
Able to read and understand informed consent document
Need for implants to replace missing tooth or teeth in at least one quadrant of the mouth.
Insufficient alveolar ridge width for endosseous implant placement defined as 5mm or less as determined by bone sounding and cone beam computed tomography (CBCT) scan.

Exclusion

Non-English speaking
Less than 18 years old
Smokers/tobacco users (\>10 cigarettes/day)
Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing
Patient is a poor compliance risk (i.e., poor oral hygiene, history of alcohol or drug abuse)
Vertical loss of bone at edentulous ridge.

What this trial measures

  • Quantitative histomorphometric evaluation of new bone formation 4 months after GBRFrom baseline to 4 months

    To quantify the distribution of the different tissues (new bone, soft tissue, residual graft and artifact) after 4 months of healing. Hence, the primary outcome will be the new bone formation, defined as the percentage of new bone area in the histomorphometric sections.