Reducing Alzheimer's Risk Through Exercise in African Americans with Mild Cognitive Impairment
This study, called RAATE-MCI, is looking at how physical activity might help reduce the risk factors for Alzheimer's disease in older African American adults. It compares a physical activity program to a "Successful Aging" program. The physical activity program involves supervised group sessions twice a week for about 80 minutes, focusing on aerobic, strength, flexibility, and balance exercises. The Successful Aging group has a low-intensity activity and health education component. The study aims to see if these programs can improve executive function (the ability to plan and organize) and episodic memory (memory for events) over 52 weeks. You may be able to join if you are an African American adult aged 60 or older, are physically able to exercise, and can attend group sessions. The current recruitment status is unclear.
- Study design
- This is a 52-week randomized controlled trial, meaning participants will be randomly assigned to one of two groups. The study plans to enroll 144 African American adults.
- What's involved
- You would attend supervised group sessions for either 80 minutes twice a week for the physical activity group, or 60 minutes once a week for the first 6 months and then every other week for the next 6 months for the successful aging group. Assessments will be done at the start, at 24 weeks, and at 52 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 52 weeks after starting the intervention, with assessments at 24 and 52 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Reducing African American's Alzheimer's Risk Through Exercise-Mild Cognitive Impairment (RAATE-MCI)
At a glance
Conditions
NCT04956549
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Pennington Biomedical Research
Baton Rouge, Louisianastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Robert L Newton, Jr., PhD · PRINCIPAL_INVESTIGATOR · Pennington Biomedical Research
- Owen Carmichael, PhD · PRINCIPAL_INVESTIGATOR · Pennington Biomedical Research
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Change in executive functionBaseline, 24 weeks, 52 weeks
The primary outcome measure will be executive function measured by the NIH-Toolbox Cognitive Battery. The NIH Toolbox Executive Function subdomain consists of the Flanker Inhibitory Control and Attention Test and the Dimensional Change Card Sort Test. The Flanker test is a measure of one's ability to inhibit attention to irrelevant conditions. Participants must identify the direction of a central visual stimuli amongst flanking stimuli either congruent or incongruent with the central stimuli. There are 40 trials and scores range from 0 - 10. The Card Sort is a measure of the ability to shift attention based on rules. Participants must match a target visual stimuli to either a color or word stimuli and this matching shifts during the assessment.
- Change in episodic memoryBaseline, 24 weeks, 52 weeks
The Rey Auditory Verbal Learning Test (RAVLT) is a common neuropsychological tool used to evaluate episodic memory. The RAVLT involves providing participants with 15 unrelated words and asking them to recall the word list. There are 5 trials designed to determine short-term memory and then a 30 minute delay to assess long-term memory. The total words correct in both the short- and long-term trials are used as outcome measures.