Motor Network Physiology Study for Parkinson's Disease and Essential Tremor
This study is investigating how brain networks control movement in people with Parkinson's disease (PD) and essential tremor (ET). Researchers believe that these conditions involve abnormalities in these brain networks. The study will look at how two treatments, Apomorphine Injectable Solution and Subcortical Stimulation (a type of deep brain stimulation), affect these networks. The goal is to better understand how these treatments work and how they relate to symptoms and movement. You may be able to join if you are 18-89 years old, have Parkinson's disease and are recommended for deep brain stimulation, and can cooperate during a conscious surgical procedure. The study plans to enroll 120 participants, but its current status is unclear.
- Study design
- This is an interventional study planning to enroll 120 participants. It will involve applying Apomorphine Injectable Solution and Subcortical Stimulation.
- What's involved
- You would need to undergo a conscious operative procedure for up to 40 minutes. Cortical ECoG and subcortical recordings, along with behavioral assessments, will be measured at baseline.
- Compensation
- Not stated in the trial record.
- Follow-up
- Not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Motor Network Physiology
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Nader Pouratian, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Texas Southwestern Medical Center
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- cortical ECoG and subcortical recordingsbaseline
Cortical ECoG and subcortical LFP recordings will occur during DBS implantation surgery during the behavioral assessments and/or Inbrija administration.
- Behavioral assessmentbaseline
Each patient will complete a task that assesses the kinematics of movement, self-initiation of movement, and/or effect of Inbrija on movement