This study is testing if cefixime (an oral medication) works as well as benzathine penicillin G (an injection) for treating syphilis. Researchers want to find another effective treatment, especially for people with HIV, to help with penicillin shortages and offer options for those with penicillin allergies. You might be able to join if you are 18 or older and have primary, secondary, or early latent syphilis with a specific blood test result (RPR titer ≥1:8). If you have HIV, you must be on treatment and have a low viral load or a CD4 count ≥ 350. The study will look at how well the treatments work after 6 months. The current recruitment status is unclear, but the study plans to enroll 400 participants.

Study design

This is a randomized, multisite, open-label study comparing two treatments. It plans to enroll 400 participants.

What's involved

You would take cefixime twice a day for 10 days or receive one injection of benzathine penicillin G. You will have follow-up visits every 3 months for 9 months to check your progress.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for 9 months after treatment to monitor clinical outcomes and serological response.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.