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Individualized Caloric Refeeding for Atypical Anorexia Nervosa

This study is comparing two ways to help hospitalized patients with atypical anorexia nervosa (AAN) regain their health. AAN is a condition where people experience significant weight loss and malnutrition but are at a 'normal' weight. The study is testing Individualized Caloric Refeeding (ICR) against the current standard, Higher Calorie Refeeding (HCR). ICR starts with calories based on body weight and increases daily, while HCR starts at 2000 calories and increases daily. The main goal is to see which method helps patients become medically stable faster in the hospital. You might be able to join if you are 12-24 years old, have AAN, and are medically unstable. The study aims to enroll 74 participants.

Study design
This is an interventional study comparing two different refeeding methods. It plans to enroll 74 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will follow participants for clinical remission over one year after hospitalization.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04966858

Individualized Study of Refeeding to Optimize iNpatient Gains

Enrolling by Invitation
NAAges 12–24InterventionalTreatment
University of California, San Francisco
~74 participants
Updated 2026-01-23 on ClinicalTrials.gov
What's tested:Individualized Caloric Refeeding (ICR)Higher Calorie Refeeding (HCR)

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Time to Achieve Medical Stability in Hospital
Measured over Inpatient hospitalization from day of admission to day of discharge, average 1-2 weeks

Conditions

Atypical Anorexia Nervosa

Explore related trials

Atypical anorexia nervosaMalnutrition

Where it's being run

2 sites across 1 states
California2

Study leadership

  • Andrea K Garber, RD, PhD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
  • Neville H Golden, MD · PRINCIPAL_INVESTIGATOR · Stanford University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 12-24 yrs
Meets Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for AAN
Hospitalized with medical instability, as defined by:

Exclusion

Bulimia nervosa
Current pregnancy
Chronic disease (e.g. immune, renal disease)
Acute/active suicidality or psychosis
Hospital admissions for refeeding in the prior 6 mo.

What this trial measures

  • Time to Achieve Medical Stability in HospitalInpatient hospitalization from day of admission to day of discharge, average 1-2 weeks

    Medical stability will be adjudicated by a five-point index: (1) 24 hour heart rate of 45 beats/min or more, (2) systolic blood pressure of 90 millimeters of mercury (mmHg) or more, (3) temperature of 35.6° C or more, (4) orthostatic increase in heart rate of 35 beats/min or less, (5) orthostatic change in systolic blood pressure of 20 mmHg or less.