Clarifying the Optimal Application of SLT Therapy Trial for Glaucoma and Ocular Hypertension

This study is looking at two ways to use Selective Laser Trabeculoplasty (SLT) for people with glaucoma and ocular hypertension (high pressure in the eye). Researchers want to see if using SLT at a low energy level works as well as the standard energy level. They also want to find out if having low energy SLT once a year can prevent or delay the need for daily eye drops better than waiting for the treatment to wear off before repeating it. You might be able to join if you are 18 or older, in good health, and have high-risk ocular hypertension or glaucoma. The study will measure how long the treatment works over 12 and 48 months. The current recruitment status is unclear, and the study plans to enroll 790 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It aims to enroll 790 participants to compare Low Energy SLT and Standard Energy SLT.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months and then again at 48 months to see how long the treatment is effective.

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NCT04967989

Clarifying the Optimal Application of SLT Therapy Trial

Recruiting
PHASE3Ages 18+InterventionalTreatment
University of Pittsburgh
~790 participants
Updated 2026-08-14 on ClinicalTrials.gov
What's tested:Low Energy SLTStandard Energy SLT

At a glance

Recruiting sites
27 of 29 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
12-month survival
Measured over 12 months
+1 more outcome measured
Glaucoma and Ocular Hypertension
29 sites across 17 states
California4
Pennsylvania4
Illinois3
Massachusetts3
Michigan2
Ohio2
Colorado1
Florida1
  • Tony Realini, MD, MPH · STUDY_CHAIR · West Virginia University
  • Goundappa K Balasubramani, PhD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh
  • Stephen Wisniewski, PhD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

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  • 12-month survival12 months

    Survival of first SLT through Month 12

  • 48-month survival48 months

    At Month 12, subjects are randomized to repeat SLT either annually at low energy or PRN at standard energy. The proportion controlled with SLT alone at Month 48 will be compared between groups