Natural History Study of Parathyroid Disorders

This study is looking to understand more about parathyroid disorders, which affect how your body controls calcium. Researchers want to find out what causes these conditions, how they develop over time, and if there are specific markers (biomarkers) in your body that can help identify them. They will do this by studying information and samples from people with conditions like parathyroid cancer, primary hyperparathyroidism, and other related bone or endocrine (hormone) disorders. The goal is to learn more about these conditions to improve care in the future. This is an observational study, meaning you would receive standard medical care for your condition, and researchers would collect data from that care. The study aims to enroll 3000 participants.

Study design
This is an observational study that plans to include 3000 participants. It is not testing a specific drug or intervention.
What's involved
Participants will receive standard medical care for their condition. Data obtained during this testing will be used for research, and samples may also be collected.
Compensation
Not stated in the trial record.
Follow-up
The study aims to identify biomarkers and investigate causes and mechanisms over a 5-year period.

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NCT04969926

Natural History Study of Parathyroid Disorders

Recruiting
Not specifiedAges 6+Observational
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
~3,000 participants
Updated 2026-08-24 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To identify biomarkers of the disease and associated manifestations by performing molecular profiling of available biospecimens
Measured over 5 years
+1 more outcome measured
Parathyroid Cancer
Primary Hyperparathyroidism
Pseudohypoparathyroidism
Inheritable Bone Diseases
Multiple Endocrine Neoplasia, Type 1
1 sites across 1 states
Maryland1
  • Smita Jha, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

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Eligibility criteria

Inclusion

Subjects known to have, suspected of having, or at risk of developing a parathyroid or related disorder.
Age \>= 6 months.

Exclusion

Children \<= 6 months
Patients with conditions that in the opinion of the investigators can interfere with the study objectives.
  • To identify biomarkers of the disease and associated manifestations by performing molecular profiling of available biospecimens5 years

    Participants will undergo standard clinical evaluations for their condition. Data obtained during these evaluations will be retained for purposes of the primary objective, for analysis of secondary objectives, and for future research. There are no mandatory study procedures for this protocol.

  • To investigate the cause and molecular mechanism of the disease, possibly genetic in participants with unknown cause of parathyroid and related disorder(s)5 years

    Participants will undergo standard clinical evaluations for their condition. Data obtained during these evaluations will be retained for purposes of the primary objective, for analysis of secondary objectives, and for future research. There are no mandatory study procedures for this protocol.