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Breathing Muscle Training in Cardiac Rehab for Heart Failure

This study is looking at whether adding inspiratory muscle training (a type of breathing exercise) to cardiac rehabilitation can improve how your blood flows and your blood pressure responds during exercise. We are looking for adults aged 18 and older who speak English. This includes people with heart failure who are eligible for cardiac rehabilitation, as well as healthy individuals. The study will measure changes in your blood pressure, blood flow, and how much resistance your blood vessels have (limb vascular resistance) at the beginning and after 12 weeks. The current status of this study is unclear, and it plans to enroll 42 participants.

Study design
This interventional study plans to enroll 42 participants. It is not specified if it is randomized or blinded.
What's involved
Participants will receive inspiratory muscle training for 12 weeks. Blood pressure, blood flow, and limb vascular resistance will be measured at the start and after 12 weeks.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 weeks, with measurements taken at baseline and at the 12-week follow-up.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04984473

A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

Recruiting
NAAges 18+Interventional
Mayo Clinic
~42 participants
Updated 2026-07-17 on ClinicalTrials.gov
What's tested:Inspiratory muscle training

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Blood pressure response
Measured over baseline and 12 week follow up
+2 more outcomes measured

Conditions

Healthy
Heart Failure

Explore related trials

HealthyHeart Failure

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Joshua Smith, PhD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Eric Bruhn, MA
[email protected]
507-266-2690
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adult 18 years and older.
English speaking.
Has a qualifying heart failure indication for center-based cardiac rehabilitation.
Adult 18 years and older.
English speaking.
Absence of pulmonary, cardiovascular, musculoskeletal, neurologic, or orthopedic diseases. Controls will be matched for age and sex.

Exclusion

HF patients who are unable to engage in a regularly structured exercise training program as part of a clinically indicated center-based outpatient cardiac rehabilitation program.
Participants unable/unwilling to provide informed consent.
Uremia, history of allergy to iodides. Impaired renal function.
Creatinine value greater than 1.3 mg/dL (via clinical record within the past 6 months).
Diagnosis of liver disease.

What this trial measures

  • Blood pressure responsebaseline and 12 week follow up

    Mean arterial pressure

  • Change in blood flow responsebaseline and 12 week follow up

    respiratory muscle blood flow

  • Change in limb vascular resistance responsebaseline and 12 week follow up

    Limb vascular resistance