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Improving Respiratory Culture Use in Critically Ill Children

This study is looking at ways to safely reduce how often respiratory cultures (tests to identify germs in the lungs) are used in critically ill children. It's an observational study, meaning researchers will watch and learn from hospitals that are already trying to improve how they use these cultures. The goal is to see if these efforts can lead to less antibiotic use without harming patients. Researchers will compare information from before and after hospitals start these improvement programs. This study aims to help hospitals reduce unnecessary antibiotic use in children with conditions like Ventilator Associated Pneumonia (a lung infection from being on a breathing machine) and Tracheobronchitis (inflammation of the windpipe and bronchial tubes). The study is currently unclear on its recruitment status.

Study design
This is an observational study involving at least 10 institutions, not individual patients. It is a quasi-experimental study comparing outcomes before and after quality improvement programs are implemented.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, Respiratory Culture Rate, will be measured for up to 42 months.

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NCT04987840

A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children

Enrolling by Invitation
Not specifiedAll AgesObservational
Johns Hopkins University
~15 participants
Updated 2026-06-08 on ClinicalTrials.gov

At a glance

Recruiting sites
0 of 8 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Respiratory Culture Rate
Measured over up to 42 months

Conditions

Ventilator Associated Pneumonia
Tracheobronchitis

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Diagnostic Stewardship

Where it's being run

8 sites across 7 states
Tennessee2
Maryland1
Massachusetts1
Minnesota1
Nebraska1
Ohio1
Texas1

Study leadership

  • Aaron Milstone, MD, MHS · PRINCIPAL_INVESTIGATOR · Johns Hopkins University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Institutions that plan to develop and implement a quality improvement program to reduce respiratory culture use in their Pediatric ICUs

Exclusion

Institutions that do not plan to develop and implement a quality improvement program to reduce respiratory culture use in their Pediatric ICUs

What this trial measures

  • Respiratory Culture Rateup to 42 months

    Rate of endotracheal aspirate cultures; Change in respiratory cultures per 100 ventilator-days per month