This study is looking at how a special type of MRI, called 129Xe Hyperpolarized MRI, can help us understand pulmonary hypertension (high blood pressure in the lungs). Researchers want to see how changes in your lung tissue, at a very small level, are connected to how well your lungs exchange gases and how blood flows through them. They will use 129Xe Hyperpolarized MRI to track these changes over time and see if it can provide more information than standard tests. You might be able to join if you are between 18 and 75 years old, are awaiting a lung transplant, and have a diagnosis of precapillary pulmonary hypertension. The study aims to understand how lung changes relate to disease progression or treatment over five years.

Study design

This interventional study plans to enroll 12 participants. It is not specified if it is randomized or blinded.

What's involved

Participants will undergo 129Xe MRI scans. For some, this will be followed by a pathological assessment of explanted lung tissue after transplant. Others will have 6-month follow-up appointments including labs, echocardiography, six-minute walk distance, and 129Xe MRI.

Compensation

Not stated in the trial record.

Follow-up

The study will measure outcomes at 5 years, suggesting a long-term follow-up period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.