Study Comparing Local/MAC Anesthesia in Lumbar Decompression

This study is looking at different types of anesthesia for people having surgery for lumbar spinal stenosis (a narrowing of the spinal canal in the lower back). Researchers want to see if using a local anesthetic (Lidocaine) combined with a relaxing medication (Propofol) is as effective and safe as general anesthesia (being completely asleep). You could be eligible if you are between 40 and 95 years old and need surgery for lumbar stenosis in 1 to 3 segments of your spine. The study will measure changes in your disability (using the Oswestry Disability Index score) and your pain levels for up to two years after surgery to see how well each anesthesia method works. The current recruitment status is unclear, but the study plans to enroll 100 participants.

Study design
This is an interventional study where 100 participants aged 40-95 will be randomly assigned to receive either general anesthesia or local anesthesia with Propofol for their lumbar decompression surgery.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for changes in disability and pain from the start of the study through year 2.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04992572

Study Comparing Local/ MAC Anesthesia in Lumbar Decompression

Recruiting
EARLY_PHASE1Ages 40–95InterventionalTreatment
Stanford University
~100 participants
Updated 2026-03-20 on ClinicalTrials.gov
What's tested:Propofol InjectionLidocaine Hydrochloride, Injectable

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Oswestry Disability Index (ODI) score
Measured over Basline through year 2
+1 more outcome measured
Lumbar Spinal Stenosis
2 sites across 1 states
California2
  • Todd Alamin, MD · PRINCIPAL_INVESTIGATOR · Stanford University

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Ages 40-95
Appropriate for general anesthesia

Exclusion

Planned significant nerve root retraction
Previous fusion operation
Unable to comply with follow up
Patients with daily morphine equivalents or more 100mg
Patients with a known hypersensitivity to propofol or any of DIPRIVAN Injectable Emulsion components.
Patients with allergies to eggs, egg products, soybeans or soy products.
  • Change in Oswestry Disability Index (ODI) scoreBasline through year 2

    Scale is expressed as a percentage (0 to 100%). Higher score indicates more severe disability.

  • Change in patient reported painBasline through year 2

    Measured on visual analog scale (VAS). Score range 0-10, 0= no pain and 10 = worst pain.