Ultrasonic Perfusion Imaging in Post-Mastectomy Irradiated Patients

This study is looking at how blood flows to the skin of the breast after a mastectomy (surgery to remove the breast) and radiation therapy. Researchers want to see how this blood flow changes before and after a procedure called fat grafting, where fat is moved from one part of your body to your breast. They are specifically interested in how fat grafting might help with radiation fibrosis (scarring from radiation). This study is for women aged 18 and older who have had a mastectomy and radiation therapy, and are having breast reconstruction with a tissue expander or implant. The main goal is to measure radiation fibrosis after 12 months. The study plans to enroll 15 participants, but its current recruitment status is unclear.

Study design
This is an interventional study that plans to enroll 15 women. It is not specified if it is randomized or blinded.
What's involved
Participants will undergo fat grafting. Blood supply to the breast skin will be evaluated after radiation therapy, and before and after fat grafting.
Compensation
Not stated in the trial record.
Follow-up
Radiation fibrosis will be measured at 12 months after the intervention.

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NCT04992650

Ultrasonic Perfusion Imaging in Post-mastectomy Irradiated Patients

Enrolling by Invitation
NAAges 18+InterventionalDiagnostic
Mayo Clinic
~15 participants
Updated 2026-06-01 on ClinicalTrials.gov
What's tested:Fat grafting

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Radiation Fibrosis
Measured over 12 months
Breast Reconstruction
Radiation Dermatitis
Radiation Fibrosis
Fat Grafting
1 sites across 1 states
Minnesota1
  • Christin A. Harless, M.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Breast cancer patients undergoing immediate tissue expander or implant reconstruction requiring radiation therapy
Have undergone mastectomy

Exclusion

Patients who are unwilling to participate
  • Radiation Fibrosis12 months

    Number of subject to experience radiation fibrosis