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Exercise for Ovarian or Endometrial Cancer Patients Receiving Chemotherapy

This study is looking at whether a 16-week, virtually supervised exercise program can help patients with ovarian or endometrial cancer who are receiving their first round of carboplatin and paclitaxel chemotherapy after surgery. The exercise program involves aerobic and resistance training three days a week. It is being compared to a home-based stretching program. Researchers want to see if the exercise program improves leg function, reduces numbness or tingling from chemotherapy (chemotherapy-induced peripheral neuropathy), and affects inflammation markers in the blood. About 30 women with newly diagnosed Stage III-IV ovarian or endometrial cancer, who are at least 18 years old and have their doctor's approval for exercise, can join. This study is currently recruiting participants.

Study design
This is a randomized controlled trial comparing an exercise group to a stretching group, with about 30 participants. The study does not specify a phase.
What's involved
Participants will either follow a 16-week virtually supervised exercise program or a home-based stretching program. There will be screening for eligibility, study interventions, evaluations, and follow-up visits.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, such as completion rates, are measured at 16 weeks.

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NCT04997096

Exercise as a Preventive Agent to Combat Immobility in Patients With Ovarian or Endometrial Cancers Receiving Chemotherapy

Recruiting
NAAges 18+InterventionalSupportive care
Dana-Farber Cancer Institute
~30 participants
Updated 2026-02-19 on ClinicalTrials.gov
What's tested:ExerciseAttention Control

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of patients completing the exercise intervention sessions.
Measured over 16 Weeks
+1 more outcome measured

Conditions

Ovarian Cancer
Ovarian Carcinoma
Ovarian Cancer Stage IV
Ovarian Cancer Stage III
Ovarian Cancer Stage 3
Endometrial Cancer
Endometrial Cancer Stage

Explore related trials

Endometrial CarcinomaMalignant Ovarian Neoplasm

Where it's being run

1 sites across 1 states
Massachusetts1

Study leadership

  • Christina Dieli-Conwright, PhD · PRINCIPAL_INVESTIGATOR · Dana-Farber Cancer Institute

Who to contact

Christina Dieli-Conwright, PhD
[email protected]
(617) 582-8321
Email the study team

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Eligibility criteria

Inclusion

Newly diagnosed patients with stages III-IV ovarian or endometrial cancer
Receiving first-line carboplatin and paclitaxel chemotherapy after surgery
≥18 years, children under the age of 18 will be excluded due to rarity of disease
Physician's clearance to participate in moderate-vigorous intensity exercise
Able to read, write, and understand English
Ability to understand and the willingness to sign an informed consent document
Willing to undergo two venous blood draws for the study

Exclusion

Pre-existing musculoskeletal, neurological, or cardiorespiratory conditions, as determined by the treating oncologist
Participants with uncontrolled intercurrent illness, as determined by the treating oncologist
Participants with psychiatric illness/social situations that would limit compliance with study requirements, as determined by the treating oncologist
Participants who have received prior chemotherapy for cancer treatment (e.g. taxanes for breast cancer)

What this trial measures

  • Proportion of patients completing the exercise intervention sessions.16 Weeks

    The feasibility of the 16-week exercise intervention is defined as the proportion of patients completing the exercise intervention sessions. The analysis population will be the eligible patients who are assigned to the intervention group (N=20). The investigators will estimate the proportion and corresponding 95% exact confidence interval (CI).99 The Investigators expect that the proportion is 70% or higher

  • Enrollment Rate16 Weeks

    The enrollment rate is defined as the proportion of patients who participate in the study among those patients who are approached for the enrollment.