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Inspiratory Muscle Strength Training for Blood Pressure in Postmenopausal Women

This study is looking at two ways to lower high blood pressure in postmenopausal women: inspiratory muscle strength training (breathing exercises) and brisk walking. Researchers want to see if inspiratory muscle strength training is better than brisk walking at lowering your blood pressure and improving how well your blood vessels work (endothelial function). You may be able to join if you are a postmenopausal woman aged 50 or older, have a systolic blood pressure (the top number) of 120 mmHg or higher, and have not used hormone therapies recently. The main goal is to see how much your blood pressure changes after 3 months. The current status of this study is unclear, and it plans to enroll 90 participants.

Study design
This is a randomized study comparing two interventions in postmenopausal women. It aims to enroll 90 participants.
What's involved
Participants will perform either inspiratory muscle strength training or brisk walking. The primary endpoint will be measured at 3 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for changes in blood pressure at 3 months.

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NCT05000515

Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise

Recruiting
NAAges 50+InterventionalTreatment
University of Colorado, Boulder
~90 participants
Updated 2026-01-14 on ClinicalTrials.gov
What's tested:High-resistance inspiratory muscle strength trainingAerobic exercise

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from baseline in casual systolic and diastolic blood pressure at 3 months
Measured over 3 months

Conditions

Aging
Blood Pressure
Endothelial Dysfunction
Hypertension

Explore related trials

Hypertension

Where it's being run

1 sites across 1 states
Colorado1

Study leadership

  • Douglas R Seals, PhD · PRINCIPAL_INVESTIGATOR · University of Colorado, Boulder

Who to contact

Daniel H Craighead, PhD
[email protected]
303-492-3010
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Postmenopausal women (\>12 months of amenorrhea)
Estrogen deficient (no hormone therapies within the previous 12 months)
Age 50 years and older
Ability to provide informed consent
Willing to accept random assignment to condition
Resting systolic blood pressure of 120 mmHg or greater
Body mass index \<40 kg/m2
Weight stable in the prior 3 months (\<2 kg weight change) and willing to remain weight stable throughout study
No change in blood pressure medications or other medications (prescription or dosing) in the prior 3 months and willing to maintain current medication regimen
Free from clinical disease with the exception of hypertension

Exclusion

Younger than age 50 years
Early menopause (menopause before age 45 years)
Having had a hysterectomy
History of uncontrolled hypertension (systolic blood pressure \>180 mmHg and/or diastolic blood pressure \>120 mmHg)
Current smoker
Alcohol dependence or abuse
Abnormal blood pressure response to exercise (drop in systolic blood pressure below resting levels or systolic blood pressure \>260 mmHg or diastolic blood pressure \>115 mmHg)
Regular vigorous aerobic/endurance exercise (\>4 bouts/week, \>30 min/bout at a workload \>6 METS)

What this trial measures

  • Change from baseline in casual systolic and diastolic blood pressure at 3 months3 months

    casual systolic and diastolic blood pressure