This study is looking at how metabolic surgery, like Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), affects the bacteria in your gut (gut microbiota) and how this relates to your heart health over time. Researchers want to understand if changes in gut bacteria after surgery can help prevent heart problems in people with conditions like type 2 diabetes, high blood pressure, and high cholesterol. You may be able to join if you are between 21 and 65 years old, are approved for metabolic surgery at Vanderbilt University Medical Center, and have a history of type 2 diabetes, high blood pressure, or high cholesterol. The study will look at your risk of heart disease for up to 10 years after surgery. The current status of this study is unclear.

Study design

This is an observational study involving 300 participants. It will follow people over time to see how their gut bacteria change after metabolic surgery.

What's involved

You would need to provide personal information and biological samples (stool, blood, and/or tissue) before and after your surgery.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed from before surgery to 1 to 3 years after surgery, and then up to 10 years after surgery to assess their risk of heart disease.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.