Antibiotic Use with External Ventricular Drains (EVDs) Study
This study is looking at the best way to use antibiotics to prevent infections in patients who need an external ventricular drain (EVD). An EVD is a tube placed in the brain to help manage pressure or fluid buildup, often after conditions like a subarachnoid hemorrhage (bleeding around the brain) or intracerebral hemorrhage (bleeding inside the brain). The study compares two approaches: giving Nafcillin for 24 hours, or giving Nafcillin for the entire time the EVD is in place. If you are allergic to penicillin, Doxycycline will be used instead. The main goal is to see which approach leads to fewer ventriculostomy related infections (VRIs), which are infections linked to the EVD. You may be eligible if you are over 18 and need an EVD for conditions like subarachnoid hemorrhage or intracerebral hemorrhage. The study is currently unclear about its recruitment status and plans to enroll 84 participants.
- Study design
- This is an interventional study comparing two different antibiotic treatment durations. It plans to enroll 84 participants.
- What's involved
- You would receive either 24 hours of antibiotics or continuous antibiotics for the duration of your external ventricular drain. The study will monitor for infections from EVD insertion until discharge, estimated to be about 2 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed from EVD insertion until discharge, which is an estimated period of 2 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- David C Altschul, MD · PRINCIPAL_INVESTIGATOR · Montefiore Medical Center
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Number of Participants with Cerebrospinal Fluid Positive (CSF+) VRIFrom EVD insertion until discharge - estimated period of time is 2 weeks
A VRI will be defined as an infection of the CNS including abscess (when occurring after EVD placement), ventriculitis, or meningitis. To receive a diagnosis of meningitis or ventriculitis, NHSN criteria (1) OR (2) must be met: 1. Patient has organism(s) identified from CSF by a culture or non-culture based microbiological method (PCR) performed for purposes of clinical diagnosis or treatment OR 2. Patient has 2 or more of: 1. fever (\>38.0°C) or headache 2. meningeal sign(s) 3. cranial nerve sign(s) AND 1 or more of: 4. increased white cells, elevated protein, and decreased glucose in CSF (per reporting lab's reference range) 5. organism(s) seen on Gram stain of CSF 6. organism(s) identified from blood by a culture or non-culture based microbiologic testing method performed for purposes of clinical diagnosis or treatment (not Active Surveillance Culture/Testing) 7. diagnostic single antibody titer (IgM) or 4-fold increase in paired sera (IgG) for organism