Imaging Brain Interactions in Cocaine Use Disorder
This study is looking at how certain brain systems, specifically those involving nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF), interact in people with cocaine use disorder (CUD). You would receive two PET scans (a special type of imaging) using a radiotracer called [C-11]NOP-1A, one before and one after receiving an intravenous dose of hydrocortisone (a medication). Researchers want to see how these brain interactions change and if they can predict relapse in CUD. The study aims to enroll 80 participants and is currently unclear on its recruitment status. To join, you must be between 18 and 55 years old and have a cocaine use disorder.
- Study design
- This interventional study plans to enroll 80 participants. It is not specified if it is randomized or blinded.
- What's involved
- You would undergo two PET scans, one at baseline and another 3 hours after receiving intravenous hydrocortisone.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint is measured at baseline and 3 hours post-hydrocortisone. Longer-term follow-up is not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Imaging CRF X NOP Interactions in CUD
At a glance
Conditions
NCT05008146
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Pittsburgh
Pittsburgh, Pennsylvaniastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Rajesh Narendran, MD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- DELTA VTBaseline, and 3 hours post-hydrocortisone
VT is the volumes of distribution expressed relative to total plasma ligand concentration; Delta VT is the change in VT from baseline to 3-hours post-hydrocortisone.