Heart Health in Locally Advanced Lung Cancer Patients Receiving Chemoradiation

This study is for people with non-small cell lung cancer that has spread to nearby tissue or lymph nodes (locally advanced). It aims to understand how chemoradiation treatment affects your heart and overall heart fitness. Researchers will use tests like the 6 Minute Walk Functional Test, echocardiograms (ultrasound of the heart), and stress tests to see if your heart health changes. They also want to see if personalizing your cancer treatment based on your individual risk can help protect your heart. The study will look for an increase in a heart injury marker (hs-TnT) and serious heart problems within 12 months of finishing treatment. This study plans to enroll 100 participants.

Study design
This is an interventional study, meaning you will receive specific tests and procedures. It plans to enroll 100 participants.
What's involved
You will undergo various tests including a 6 Minute Walk Functional Test, blood and urine collection, CT scans, echocardiograms, and stress tests at different times before, during, and after your chemoradiation treatment. This will occur over a period of up to 24 months for some tests.
Compensation
Not stated in the trial record.
Follow-up
After completing study treatment, you will be followed annually for up to 10 years.

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NCT05010109

Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation

Recruiting
NAAges 18+InterventionalDiagnostic
M.D. Anderson Cancer Center
~100 participants
Updated 2026-03-11 on ClinicalTrials.gov
What's tested:6 Minute Walk Functional TestBiospecimen CollectionComputed TomographyEchocardiographyExercise Cardiac Stress TestQuestionnaire Administration

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Increase in level of hs-TnT >= 5ng/L
Measured over up to 24 months
+1 more outcome measured
Locally Advanced Lung Non-Small Cell Carcinoma
Stage III Lung Cancer AJCC v8
Stage IIIA Lung Cancer AJCC v8
Stage IIIB Lung Cancer AJCC v8
Stage IIIC Lung Cancer AJCC v8
1 sites across 1 states
Texas1
  • Zhongxing Liao, MD · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center

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  • Increase in level of hs-TnT >= 5ng/Lup to 24 months

    Baseline up to end or chemoradiation (CRT)

  • Incidence of grade >= 2 cardiovascular eventsWithin 12-month of completion of CRT]

    Defined by Common Terminology Criteria for Adverse Events version 5.0.