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Laser Ablation and Radiosurgery for Spine Metastases

This study is testing a new way to treat spinal tumors (spine metastases) that are close to the spinal cord. It combines two treatments: Stereotactic Laser Ablation (using a laser to destroy tumors) and Stereotactic Radiosurgery (precise radiation to the tumor). The goal is to improve how well the tumor is controlled, reduce pain, maintain your physical abilities, and improve your quality of life. We are also looking at how effective these combined treatments are for spinal tumors that are pressing on the spinal cord. You may be able to join if you are over 18 years old and have a solid tumor that has spread to your spine. We will measure how well the tumor is controlled for up to 24 months. The current status of this study is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 60 participants.
What's involved
Participants will undergo MRI-guided laser ablation and stereotactic radiosurgery. Follow-up assessments will occur at 1, 3, 6, 9, 12, 18, and 24 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 24 months to assess tumor control and other outcomes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05023772

Laser Interstitial Thermal Ablation and Stereotactic Radiosurgery for Patients With Spine Metastases

Recruiting
NAAges 18+InterventionalTreatment
Henry Ford Health System
~60 participants
Updated 2026-06-03 on ClinicalTrials.gov
What's tested:Stereotactic Laser AblationStereotactic RadiosurgeryMRI guided laser ablation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Local Tumor Control Rate
Measured over up to 24 months

Conditions

Neoplasm Metastasis
Spinal Cord Diseases
Spinal Cord Compression
Spinal Cord Tumor
Spine Metastases

Explore related trials

Metastatic Malignant Neoplasm in the Spine

NCT05023772

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Henry Ford Hospital

    Detroit, Michiganstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Ian Lee, MD · PRINCIPAL_INVESTIGATOR · Henry Ford Health Health System

Who to contact

RAMONA DAVIS
[email protected]
3132821753
Email the study team

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Eligibility criteria

Inclusion

Age \> 18 years old. (The indication for this technique is controversial in skeletally immature patients.)

Exclusion

Quantification of the degree of epidural spinal cord compression as grade 1C, 2, or 3 by MRI, with and without contrast sequences. Axial T2 sequence is encouraged but not required.
The vertebral body site to be treated must be located from T2 to L1
No more than 3 contiguous or dis-contiguous vertebral levels involved with metastasis in the spine to be irradiated in a single session or 3 sessions.
Motor strength ≥4 out of 5 in extremity or extremities affected by the level of the spinal cord compression (see section 4 for grading method).
ECOG performance status \<2 or Karnofsky performance status (KPS) \>50
Life expectancy \>3 months.
Inoperable disease because of patient refusal, neurosurgical evaluation, or any other medical reasons.
Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) before study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately.
Prior conventional radiation to the same site is allowed as long as there is a greater than 3 months interval.
Signed informed consent.
Requires open spinal procedure or a percutaneous procedure without the use of image guidance.
Primary tumors of radiosensitive histology (lymphoma, multiple myeloma, small cell carcinoma, germ cell tumors), as conventional radiation is likely to be effective in such cases.
Unable to tolerate general anesthesia and prone position.
Unable to undergo MRI scan of the spine.
Inability to lie flat on a treatment table for \>60 minutes.
Pregnant. (Urine testing must be done no more than 10 days prior to surgery.)
Prior conventional irradiation of the spine site and level to be treated with an interval shorter than 3 months.
Frank cord compression or cord compression from bone components or configuration and acute neurological deficits (defined as motor strength \<4/5 in extremity or extremities affected by the level of the spinal cord compression)

What this trial measures

  • Local Tumor Control Rateup to 24 months

    Kaplan-Meier estimates will be used.