Pain Control After Kidney Stone Surgery

This study is looking at ways to manage pain after percutaneous nephrolithotomy (a surgery to remove kidney stones). Researchers want to see if an erector spinae plane (ESP) block, which involves injecting ropivacaine 0.5% and dexamethasone near the spine, can reduce the amount of opioid pain medication (like morphine) you need after surgery. You would be compared to a group receiving a saline placebo. The study will also check your pain levels and recovery. Adults aged 18 and older who are having this specific kidney stone surgery can participate. The study aims to enroll 128 people, but the current enrollment status is unclear.

Study design
This is a double-blind, randomized controlled trial involving 128 participants. You would be randomly assigned to receive either the ESP block or a saline placebo.
What's involved
You would have follow-up visits before surgery and at 24 hours, 48 hours, 7 days, and 30 days after surgery.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 30 days after surgery.

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NCT05024344

ESP Block vs Control for Pain Control Following Percutaneous Nephrolithotomy

Recruiting
NAAges 18+Interventional
University of Tennessee Medical Center
~128 participants
Updated 2026-04-28 on ClinicalTrials.gov
What's tested:Erector Spinae Plane BlockRopivacaine 0.5% Injectable SolutionDexamethasone

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Opioid consumption (MME)
Measured over First 24 hours postoperative
Nephrolithotomy, Percutaneous
1 sites across 1 states
Tennessee1
  • Jason Buehler, MD · PRINCIPAL_INVESTIGATOR · University of Tennessee Medical Center

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Eligibility criteria

Inclusion

Adults, male and female greater than or equal to 18 years of age and undergoing non-emergent percutaneous nephrolithotomy Monday through Friday between the hours of 6:00AM and 4:00PM.
Female participants of childbearing potential will be required to provide a negative pregnancy test.
Ability to understand and teach back consent for the procedure.
Willingness to sign consent for procedure.
English speaking.

Exclusion

Emergent surgery status.
Local infection
Allergy to local anesthetics.
Recreational drug use.
Inability to provide informed consent.
Pregnancy or breastfeeding.
History of Guillain-Barre' Syndrome.
Underlying medical conditions that would post a significant risk to the patient.
Opioid use \>90 days in the year leading up to surgery.
  • Opioid consumption (MME)First 24 hours postoperative

    Opioid consumption (MME) in the first 24 hours postoperative