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Fitness and Lung Function Study for Childhood Chronic Diseases

This study is looking at how exercise affects fitness and lung function in young people aged 8 to 25 who have survived acute lymphoblastic leukemia (ALL), live with chronic lung disease (CLD) from prematurity, or have had a heart transplant. Researchers want to better understand how these conditions impact exercise ability and heart and lung function. You would participate in a one-time study visit where your physical activity and exercise capacity will be measured. The study aims to gather information to help create better exercise guidelines for children with chronic diseases. The study is currently unclear on its recruitment status and plans to enroll 90 participants.

Study design
This is an observational study, meaning researchers will observe and collect information without providing specific treatments. It aims to enroll 90 participants.
What's involved
You would have a one-time study visit lasting 3-4 hours. During this visit, your physical activity will be reported, and your peak oxygen intake and cardiac output (how much blood your heart pumps) will be measured during exercise.
Compensation
Not stated in the trial record.
Follow-up
Measurements for primary endpoints are taken during the one-time study visit day.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05025774

Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise

Recruiting
Not specifiedAges 8–25Observational
Masonic Cancer Center, University of Minnesota
~90 participants
Updated 2025-11-24 on ClinicalTrials.gov
What's tested:Physical activity

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Measure of Peak O2 intake during test exercise
Measured over 3-4 hours during the onetime study visit day
+1 more outcome measured

Conditions

Chronic Lung Disease
Chronic Obstructive Pulmonary Disease
Acute Lymphoblastic Leukemia
Heart Transplant

Explore related trials

Acute Lymphoblastic LeukemiaChronic Lung DisorderHeart Transplantation

NCT05025774

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Masonic Cancer Center

    Minneapolis, Minnesotastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Pianosi Paolo, MD · PRINCIPAL_INVESTIGATOR · Masonic Children's Hospital, University of Minnesota

Who to contact

Char Napurski, MPH, CCRP
[email protected]
612-626-2140
Email the study team

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Eligibility criteria

Inclusion

Cases:
Acute lymphoblastic leukemia survivor, OR living with chronic lung disease of prematurity, OR living with heart transplant
8-25 years old
Height: ≥ 48 inches
Ambulatory without assistance
English speaking
Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
SpO2 \>92%
Not pregnant
ALL survivor specific: must have completed therapy ≥ 3 months prior to study entry
Controls
8-25 years old
Height: ≥ 48 inches
Ambulatory without assistance
English speaking
No history of arrhythmia or known cardiac dysfunction at baseline
Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
SpO2 \>95%
Not pregnant

Exclusion

Cases:
ALL specific: received cranial radiation, bone marrow transplant recipients
Investigator or patient's primary physician deems the patient unsuitable for the study
Controls:
History of malignancy, CLD or HT or any other diagnosis which may reduce cardiorespiratory function
Investigator deems the patient unsuitable for the study

What this trial measures

  • Measure of Peak O2 intake during test exercise3-4 hours during the onetime study visit day

    Maximal cardiopulmonary exercise testing (CPX) will be completed on cycle ergometer to determine peak oxygen uptake, a measure of cardiorespiratory fitness

  • Measure of Cardiac output during test exercise3-4 hours during the onetime study visit day

    Cardiac output is measured using C2H2 open-circuit breathing technique: a mass spectrometer medical gas analyzer will measure gas concentration continuously, yielding serial Stroke Volume measurements during incremental exercise. Cardiac output is the product of heart rate and stroke volume