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Virtual Reality 3D-Surgery Modeling for Head and Neck Cancer

This study is exploring if using virtual reality (VR) and 3D-surgery modeling can improve head and neck cancer surgery. Specifically, it's looking at how these tools might help surgeons plan better and communicate more effectively with pathologists during treatment for head and neck squamous cell carcinoma. The goal is to increase the accuracy of surgical planning and ultimately improve outcomes for patients. You might be able to join if you have head and neck cancer (oral cavity, oropharynx, larynx, hypopharynx, T1-T4) and are receiving treatment at Thomas Jefferson University - Center City, are eligible for surgery, and are over 18. The main way we'll know if this approach is successful is by looking at "margin events" (how much cancer is left at the edges of the removed tissue) right after surgery. The study's current status is unclear, and it plans to enroll 160 participants.

Study design
This is an interventional study that plans to enroll 160 participants. Participants will be randomly assigned to one of two groups: one receiving VR/3D-CEPs plus standard treatment, and the other receiving only standard treatment.
What's involved
If you are in the VR/3D-CEPs group, you will undergo virtual reality imaging before surgery. All participants will have their CT scans reviewed and then undergo surgical resection.
Compensation
Not stated in the trial record.
Follow-up
The study will assess event-free survival (recurrence at the primary site) at 18-36 months after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05031910

Virtual Reality 3D-Surgery Modeling to Enhance Head and Neck Cancer Surgery Quality

Recruiting
NAAges 18+InterventionalTreatment
Thomas Jefferson University
~160 participants
Updated 2026-02-17 on ClinicalTrials.gov
What's tested:Medical Device Usage and EvaluationBest PracticeResection

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Margin events
Measured over Up to Completion of surgical resection

Conditions

Head and Neck Squamous Cell Carcinoma

Explore related trials

Head and Neck Squamous Cell Carcinoma

Where it's being run

1 sites across 1 states
Pennsylvania1

Who to contact

Joseph Curry, MD
[email protected]
215-955-6784
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Diagnosed with cancer of the head and neck (oral cavity, oropharynx, larynx, hypopharynx, T1-T4)
Receiving treatment at Thomas Jefferson University - Center City by a fellowship-trained HNC surgeon
Eligible for definitive resection
Age \> 18
Provide signed written informed consent document

Exclusion

Impaired judgement or those unable to provide informed consent
Any factor that would place the patient at increased risk or preclude the individual's full compliance with or completion of the study
Nasopharyngeal carcinoma
Contraindications for surgery
Enrollment in other clinical trial

What this trial measures

  • Margin eventsUp to Completion of surgical resection

    Will be defined as the number of positive margins along with the number of unexpected defect driven margins. Will be collected for patients in the control group and patients treated with the use of preoperative planning with virtual reality (VR). Margin events will be defined as binary (yes/no) on post-operative survey to be completed by surgeons. Logistic regression will be used to evaluate of a difference in any margin event between study groups (3 dimensional \[3D\] VR vs. control) adjusted for surgeon.