Studying Human Immune Response to Tick Bites
This study aims to understand how your body, especially your skin, reacts to bites from deer ticks (Ixodes scapularis). Researchers hope to use this information to develop future vaccines against ticks and the diseases they carry, like Lyme disease. You may be eligible if you are a healthy adult, aged 18 or older, and have no history of tick-borne diseases or known tick bites. The study will assess the safety of using laboratory-raised ticks and develop a model of how humans might become resistant to tick bites. The study's status is currently unclear.
- Study design
- This is a single-center study planning to enroll 60 participants. It is a prospective, non-randomized study.
- What's involved
- You will undergo up to three tick feeding placements, 2 to 8 weeks apart. You will also have blood draws and skin punch biopsies from tick bite sites and unaffected skin.
- Compensation
- Not stated in the trial record.
- Follow-up
- Safety will be monitored continuously, and the development of tick resistance will be assessed at the end of the study.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Human Immune Response to Ixodes Scapularis Tick Bites
At a glance
Conditions
NCT05036707
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
National Institutes of Health Clinical Center
Bethesda, Marylandstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Adriana R Marques, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Allergy and Infectious Diseases (NIAID)
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Assessment of Safety of the device. Use toxicity tables and safety monitoring as specified in the protocol.continuous
Ongoing assessment of safety.
- Develop a model of acquired tick resistance in humans. Use validated pruritus scales, numerical rating system, verbal rating system, and visual analogue system.end of study
Clinical measures of tick immunity.