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Dietary Supplementation and Immune System Study

This study is looking at how a dietary supplement, Monosaccharide Powder, affects your immune system, specifically how it changes certain proteins (Immunoglobulin fragment crystallization modifications) in your blood. You would be randomly assigned to receive either the Monosaccharide Powder or a placebo (a sugar powder that looks the same but has no active ingredient). Researchers will be looking for changes in these proteins after 4 weeks. This study is for healthy adults between 18 and 45 years old with a healthy body mass index (BMI). The current recruitment status is unclear.

Study design
This is a randomized, double-blind, placebo-controlled study involving 44 healthy adults.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your Immunoglobulin fragment crystallization modifications will be measured at 4 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05040204

The Effects of Dietary Supplementation on Serum Protein Glycosylation

Recruiting
PHASE1Ages 18–45InterventionalBasic science
University of California, Davis
~44 participants
Updated 2026-05-28 on ClinicalTrials.gov
What's tested:Monosaccharide PowderPlacebo Comparator

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Characterize Immunoglobulin fragment crystallization modifications
Measured over 4 Weeks

Conditions

Healthy

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Emanual Maverakis, MD · PRINCIPAL_INVESTIGATOR · University of California, Davis

Who to contact

Emanual Maverakis, MD
[email protected]
916-551-2635
Email the study team

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Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

Adult men/women (age 18-45) who are in general good health with Body Mass Index (BMI) range of 18.5-25

Exclusion

Adults younger than 18 or older than 45 years of age
Women who are pregnant, actively nursing or have had a pregnancy within the last year
Women who are peri-menopausal or post-menopausal
Women with irregular menstrual cycles (more frequently than every 21 days or lasts longer than 8 days. Missed, early, or late periods are also considered signs of an irregular cycle)
Women on hormonal contraception, including birth control, hormonal intrauterine device, or contraceptive implant
Individuals with past medical history of an autoimmune condition or malignancy, excluding non-melanoma skin cancer
Individuals with cardiovascular, pulmonary, reproductive, endocrine, metabolic, neurologic, gastrointestinal, hematologic, or infectious diseases of any type
Individuals with diagnosis of galactosemia or congenital disorders of glycosylation
Individuals with phenylketonuria
Individuals currently taking prescription medications, or who have taken prescription medications within the last 3 months
Individuals currently taking over-the-counter medications
Individuals currently taking or who have taken supplements including herbal, protein or vitamin supplements in the last 3 months (e.g. whey protein, St. John's Wort, green tea supplements, biotin, creatine supplements), excluding multivitamins or essential vitamins
Individuals with BMI less than 18.5 or greater than 25
Individuals with prior history of severe food or drug allergic reactions
Individuals with allergic reaction or adverse reaction to shellfish, N-acetylglucosamine, galactose, Spirulina/chlorella/algae supplements, or arabinose containing compounds/foods/supplements
Individuals with first-degree relative with history of an autoimmune condition
Individuals with social history of current use of tobacco, alcohol or other drugs
Actively dieting or trying to lose weight
Vegan diet
Consume equal to or greater than 2 cups of tea a day
Consume equal to or greater than 4 cups of coffee a day
Consume equal to or greater than 3 cups of fruit juice a day
Practice intensive exercise patterns (marathon training, workouts \>4 hours a day)
Consume soda or energy drinks of any amount
Consume fast food equal to or greater than 5 days per week
Consume greater than one serving of alcohol per day
(1 serving of wine = 6 oz, 1 serving of beer = 12 oz, 1 serving of spirits = 1 oz)
On a carbohydrate-restricted or "Paleo" diet, or calorie-restricted diet (less than 20-25% of maintenance calories)
Adults unable to consent
Prisoners

What this trial measures

  • Characterize Immunoglobulin fragment crystallization modifications4 Weeks

    Use mass spectrometry and RNA sequencing from subject blood samples to characterize site specific glycosylation on Immunoglobulin A, Immunoglobulin M, and Immunoglobulin G.